1PZJ	Toxin	date	Jul 11, 2003
title	Cholera Toxin B-Pentamer Complexed With Nitrophenyl Galactoside 5
authors	D.D.Mitchell, J.C.Pickens, K.Korotkov, E.Fan, W.G.J.Hol
compound		source
Molecule: Cholera Toxin B Subunit Chain: D, E, F, G, H Synonym: Ctb; Cholera Toxin B Protein; Cholera Toxin Subunit B; Engineered: Yes		Organism_scientific: Vibrio Cholerae Organism_common: Bacteria Gene: Caa41591 Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Top10 Expression_system_vector_type: Plasmid Expression_system_plasmid: Pbad
symmetry	Space Group: C 1 2 1	R_factor	0.115
crystal cell	length a length b length c angle alpha angle beta angle gamma 101.754 65.998 77.362 90.00 105.44 90.00
method	X-Ray Diffraction	resolution	1.46 Å
ligand	15B, J15	enzyme
Gene Ontology	Chain Function Process Component H, F, D, G, E pathogenesis extracellular region
Primary reference	3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies., Mitchell DD, Pickens JC, Korotkov K, Fan E, Hol WG, Bioorg Med Chem 2004 Mar 1;12(5):907-20. PMID:14980603

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (226 Kb) [Save to disk] Biological Unit Coordinates (1pzj.pdb1.gz) 198 Kb CSU: Contacts of Structural Units for 1PZJ Likely Quarternary Molecular Structure file(s) for 1PZJ Structure Factors (666 Kb) Retrieve 1PZJ in mmCIF format [Save to disk]

View 1PZJ in 3D

On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1PZJ

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Structure-derived information

Conformational Epitope Prediction for 1PZJ 1PZJD 1PZJE 1PZJF 1PZJG 1PZJH from the CEP Server. Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1PZJ, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1pzjd_, region D [Jmol] [rasmolscript] [script source]     - Domain d1pzje_, region E [Jmol] [rasmolscript] [script source]     - Domain d1pzjf_, region F [Jmol] [rasmolscript] [script source]     - Domain d1pzjg_, region G [Jmol] [rasmolscript] [script source]     - Domain d1pzjh_, region H [Jmol] [rasmolscript] [script source] Fold representative 1pzj from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1pzj_G] [1pzj_H] [1pzj_D] [1pzj_F] [1pzj_E]

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