1OUV	Hydrolase	date	Mar 25, 2003
title	Helicobacter Cysteine Rich Protein C (Hcpc)
authors	P.R.Mittl, L.Luethy
compound		source
Molecule: Conserved Hypothetical Secreted Protein Chain: A Synonym: Helicobacter Cysteine Rich Protein C, Hcpc Engineered: Yes		Organism_scientific: Helicobacter Pylori Organism_common: Bacteria Strain: 26695 Gene: Hp1098 Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Bl21(De3) Expression_system_vector_type: Plasmid Expression_system_vector: T7 Expression_system_plasmid: Ptft74
symmetry	Space Group: C 1 2 1	R_factor	0.202
crystal cell	length a length b length c angle alpha angle beta angle gamma 102.982 46.198 76.390 90.00 120.95 90.00
method	X-Ray Diffraction	resolution	2.00 Å
note	1OUV is a representative structure
similarity	Contains 7 tpr repeats. Belongs to the hcp beta-lactamase family.[TPR_1]
catalytic activ.	A beta-lactam + h(2)o = a substituted beta- amino acid.
subcellular loc.	Secreted protein (potential).
gene	hcpC (H. pylori)
function	May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (aca) derivatives (by similarity).
Gene Ontology	Chain Function Process Component A binding beta-lactamase activity hydrolase activity response to antibiotic
Primary reference	The Crystal Structure of Helicobacter Cysteine-rich Protein C at 2.0A Resolution: Similar Peptide-binding Sites in TPR and SEL1-like Repeat Proteins., Luthy L, Grutter MG, Mittl PR, J Mol Biol 2004 Jul 16;340(4):829-41. PMID:15223324

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (56 Kb) [Save to disk] Biological Unit Coordinates (1ouv.pdb1.gz) 45 Kb CSU: Contacts of Structural Units for 1OUV Likely Quarternary Molecular Structure file(s) for 1OUV Structure Factors (222 Kb) Retrieve 1OUV in mmCIF format [Save to disk]

View 1OUV in 3D

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Visual 3D analysis of 1OUV

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Structure-derived information

Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1OUV, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1ouva_, region A [Jmol] [rasmolscript] [script source] Fold representative 1ouv from FSSP and Dali (Families of Structurally Similar Proteins)

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1ouv_A]

Other resources with information on 1OUV

InterPro: IPR001440 , IPR011990 , IPR006597 MMDB (Entrez's Structure Database)

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