1OSM	Outer Membrane Protein	date	Jan 08, 1999
title	Osmoporin (Ompk36) From Klebsiella Pneumoniae
authors	R.Dutzler, T.Schirmer
compound		source
Molecule: Ompk36 Chain: A, B, C Synonym: Osmoporin Engineered: Yes		Organism_scientific: Klebsiella Pneumoniae Expression_system: Escherichia Coli
symmetry	Space Group: C 1 2 1	R_factor	0.208
crystal cell	length a length b length c angle alpha angle beta angle gamma 191.800 76.800 223.400 90.00 113.30 90.00
method	X-Ray Diffraction	resolution	3.20 Å
ligand	D12	enzyme
similarity	Belongs to the gram-negative porin family.[Porin_1]
subunit	Homotrimer.
subcellular loc.	Membrane localization by OPM: Bacterial gram-negative outer membrane extracellular side periplasmic side
Genes	OMPC, OMPK36 (K. pneumoniae)
function	Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. In k.pneumoniae it has been shown to bind the c1q component and activate the classical pathway of the complement system.
Gene Ontology	Chain Function Process Component A, C, B transporter activity porin activity transport ion transport membrane integral to membrane outer membrane
Primary reference	Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae., Dutzler R, Rummel G, Alberti S, Hernandez-Alles S, Phale P, Rosenbusch J, Benedi V, Schirmer T, Structure Fold Des 1999 Apr 15;7(4):425-34. PMID:10196126

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (166 Kb) [Save to disk] Biological Unit Coordinates (1osm.pdb1.gz) 163 Kb CSU: Contacts of Structural Units for 1OSM Likely Quarternary Molecular Structure file(s) for 1OSM Structure Factors (448 Kb) Retrieve 1OSM in mmCIF format [Save to disk]

View 1OSM in 3D

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Visual 3D analysis of 1OSM

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1OSM, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1osma_, region A [Jmol] [rasmolscript] [script source]     - Domain d1osmb_, region B [Jmol] [rasmolscript] [script source]     - Domain d1osmc_, region C [Jmol] [rasmolscript] [script source] Fold representative 1osm from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1osm_B] [1osm_C] [1osm_A]

Other resources with information on 1OSM

InterPro: IPR003229 , IPR001897 , IPR001702 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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