1NYO	Immune System	date	Feb 13, 2003
title	Solution Structure Of The Antigenic Tb Protein Mpt70mpb70
authors	M.J.Bloemink, E.Dentten, R.G.Hewinson, R.A.Williamson, M.D.Carr, Tb Structural Genomics Consortium (Tbsgc)
compound		source
Molecule: Immunogenic Protein Mpt70 Chain: A Synonym: Mycobacterial Protein Mpt70, Mpb70 Engineered: Yes		Organism_scientific: Mycobacterium Tuberculosis Organism_common: Bacteria Gene: Mpt70mpb70 Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Dh5alpha Expression_system_vector_type: Plasmid Expression_system_plasmid: Pbluescript Ks+
method	NMR, 38 Structures
note	1NYO is a representative structure
similarity	Contains 1 fas1 domain.[Fasciclin]
subunit	Generally found as a monomer; homodimer in culture fluids.
subcellular loc.	Secreted protein.
genes	MT2943, mpt70 (M. tuberculosis)
Gene Ontology	Chain Function Process Component A cell adhesion
Primary reference	Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease., Carr MD, Bloemink MJ, Dentten E, Whelan AO, Gordon SV, Kelly G, Frenkiel TA, Hewinson RG, Williamson RA, J Biol Chem 2003 Oct 31;278(44):43736-43. PMID:12917404

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (1431 Kb) [Save to disk] Biological Unit Coordinates (1nyo.pdb1.gz) 1429 Kb CSU: Contacts of Structural Units for 1NYO Original NMR restraints for 1NYO from PDB Parsed, converted and filtered NMR Restraints for 1NYO in BioMagResBank (BMRB) Retrieve 1NYO in mmCIF format [Save to disk]

View 1NYO in 3D

On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1NYO

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1NYO, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1nyoa_, region A [Jmol] [rasmolscript] [script source] Fold representative 1nyo from FSSP and Dali (Families of Structurally Similar Proteins)

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1nyo_A]

Other resources with information on 1NYO

InterPro: IPR000782 MMDB (Entrez's Structure Database)

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