1M3I | Toxin | date | Jun 28, 2002 ![]() ![]() |
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title | Perfringolysin O, New Crystal Form | ||||||||||||||
authors | J.Rossjohn, M.Parker, G.Polekhina, S.Feil, R.Tweten | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Perfringolysin O Chain: A, B, C, D Engineered: Yes |
Organism_scientific: Clostridium Perfringens Organism_common: Bacteria Gene: Pfoa Expression_system: Escherichia Coli Expression_system_common: Bacteria | ||||||||||||||
symmetry | Space Group: P 31 | R_factor | 0.233 | ||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 2.90 Å | ||||||||||||
related structures | by homologous chain: 1M3J, 1PFO | ||||||||||||||
similarity | Belongs to the thiol-activated cytolysin family.[Thiol_cytolysin] | ||||||||||||||
subunit | Forms oligomers in the host membrane. | ||||||||||||||
Genes | CPE0163, PFOA, PFOR, PFO (C. perfringens) | ||||||||||||||
function | Cholesterol is the receptor for the binding of these toxins to eukaryotic cell membranes. Is able to lyse cholesterol containing membranes. Sulfhydryl-activated toxin. Can be reversibly inactivated by oxidation. | ||||||||||||||
Gene Ontology |
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Data retrieval |
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View 1M3I in 3D |
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Visual 3D analysis of 1M3I |
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Structure-derived information |
- Domain d1m3ia_, region A [Jmol] [rasmolscript] [script source] - Domain d1m3ib_, region B [Jmol] [rasmolscript] [script source] - Domain d1m3ic_, region C [Jmol] [rasmolscript] [script source] - Domain d1m3id_, region D [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
Other resources with information on 1M3I |
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