1LO5 | Immune System Toxin | date | May 06, 2002 ![]() ![]() |
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title | Crystal Structure Of The D227a Variant Of Staphylococcal Enterotoxin A In Complex With Human Mhc Class II | ||||||||||||||
authors | K.Petersson, M.Thunnissen, G.Forsberg, B.Walse | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Hla Class II Histocompatibility Antigen, Dr Alpha Chain; Chain: A Fragment: Extracellular Domain Synonym: Mhc Class II (Hla-Dr1, Dra 0101)-Chain A Engineered: Yes |
Organism_scientific: Homo Sapiens Organism_common: Human Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_vector_type: Plasmid Expression_system_plasmid: Plm1 | ||||||||||||||
Molecule: Hla Class II Histocompatibility Antigen, Dr-1 Beta Chain; Chain: B Fragment: Extracellular Domain Synonym: Mhc Class II (Hla-Dr1, Drb1 0101)-Chain B Engineered: Yes |
Organism_scientific: Homo Sapiens Organism_common: Human Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_vector_type: Plasmid Expression_system_plasmid: Plm1 | ||||||||||||||
Molecule: Hemagglutinin Peptide Chain: C Engineered: Yes |
Synthetic: Yes Other_details: This Sequence Is Peptide From Influenza Virus, Hemagglutinin Peptide; | ||||||||||||||
Molecule: Enterotoxin A Chain: D Engineered: Yes Mutation: Yes |
Organism_scientific: Staphylococcus Aureus Organism_common: Bacteria Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Ul635 Expression_system_vector_type: Plasmid Expression_system_plasmid: Plr16 Expression_system_gene: K12 | ||||||||||||||
symmetry | Space Group: P 21 21 21 | R_factor | 0.245 | ||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 3.20 Å | ||||||||||||
similarity | Belongs to the mhc class ii family. Belongs to the staphylococcal/streptococcal toxin family. Contains 1 ig-like c1-type (immunoglobulin-like) domain.[MHC_II_alpha] | ||||||||||||||
subunit | Monomer. Heterodimer of an alpha chain and a beta chain. | ||||||||||||||
polymorphism | The following alleles of drb1-1 are known: drb1*0101, drb1*0102, drb1*0103, drb1*0104, drb1*0105, drb1*0106 and drb1*0107. The sequence shown is that of dra*0101. The following alleles of dra are known dra*0102. The sequence shown is that of drb1*0101. | ||||||||||||||
subcellular loc. | Secreted protein. Membrane; single-pass type i membrane protein. | ||||||||||||||
Genes | ENTA (S. aureus); HLA-DRA1, HLA-DRA, HLA-DRB1 (H. sapiens) | ||||||||||||||
function | The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. | ||||||||||||||
Gene Ontology | |||||||||||||||
Primary reference | Crystal structure of a SEA variant in complex with MHC class II reveals the ability of SEA to crosslink MHC molecules., Petersson K, Thunnissen M, Forsberg G, Walse B, Structure (Camb) 2002 Dec;10(12):1619-26. PMID:12467569 |
Data retrieval |
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Structure-derived information |
- Domain d1lo5a2, region A:4-81 [Jmol] [rasmolscript] [script source] - Domain d1lo5a1, region A:82-182 [Jmol] [rasmolscript] [script source] - Domain d1lo5b2, region B:3-92 [Jmol] [rasmolscript] [script source] - Domain d1lo5b1, region B:93-190 [Jmol] [rasmolscript] [script source] - Domain d1lo5d1, region D:1-120 [Jmol] [rasmolscript] [script source] - Domain d1lo5d2, region D:121-233 [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
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