1LEP	Chaperone	date	Dec 13, 1995
title	Three-Dimensional Structure Of The Immunodominant Heat-Shock Protein Chaperonin-10 Of Mycobacterium Leprae
authors	S.C.Mande, W.G.J.Hol
compound		source
Molecule: Chaperonin-10 Chain: A, B, C, D, E, F, G Synonym: Ml10		Organism_scientific: Mycobacterium Leprae
symmetry	Space Group: C 2 2 21	R_factor	0.23
crystal cell	length a length b length c angle alpha angle beta angle gamma 112.900 129.000 109.500 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	3.5 Å
similarity	Belongs to the groes chaperonin family.[Cpn10]
subunit	Heptamer of 7 subunits arranged in a ring.
subcellular loc.	Cytoplasm.
gene	B229 (M. leprae)
function	Binds to cpn60 in the presence of mg-atp and suppresses the atpase activity of the latter.
Gene Ontology	Chain Function Process Component F, A, D, C, G, E, B ATP binding unfolded protein binding protein folding response to unfolded protein...
Primary reference	Structure of the heat shock protein chaperonin-10 of Mycobacterium leprae., Mande SC, Mehra V, Bloom BR, Hol WG, Science 1996 Jan 12;271(5246):203-7. PMID:8539620

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (22 Kb) [Save to disk] Biological Unit Coordinates (1lep.pdb1.gz) 13 Kb CSU: Contacts of Structural Units for 1LEP Likely Quarternary Molecular Structure file(s) for 1LEP Retrieve 1LEP in mmCIF format [Save to disk]

View 1LEP in 3D

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Visual 3D analysis of 1LEP

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1LEP, from MSDmotif at EBI Genome occurence of 1LEP's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1lepa_, region A [Jmol] [rasmolscript] [script source]     - Domain d1lepb_, region B [Jmol] [rasmolscript] [script source]     - Domain d1lepc_, region C [Jmol] [rasmolscript] [script source]     - Domain d1lepd_, region D [Jmol] [rasmolscript] [script source]     - Domain d1lepe_, region E [Jmol] [rasmolscript] [script source]     - Domain d1lepf_, region F [Jmol] [rasmolscript] [script source]     - Domain d1lepg_, region G [Jmol] [rasmolscript] [script source] Fold representative 1lep from FSSP and Dali (Families of Structurally Similar Proteins)

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1lep_B] [1lep_C] [1lep_A] [1lep_G] [1lep_D] [1lep_E] [1lep_F]

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