1KLX | Hydrolase | date | Dec 13, 2001 ![]() |
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title | Helicobacter Pylori Cysteine Rich Protein B (Hcpb) | ||||||||||||||
authors | L.Luethy, M.G.Gruetter, P.R.E.Mittl | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Cysteine Rich Protein B Chain: A Engineered: Yes |
Organism_scientific: Helicobacter Pylori Organism_common: Bacteria Gene: Hp0336 Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Bl21(De3) Expression_system_vector_type: Plasmid Expression_system_plasmid: Ptft74 | ||||||||||||||
symmetry | Space Group: P 65 2 2 | R_factor | 0.187 | ||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 1.95 Å | ||||||||||||
note | 1KLX is a representative structure | ||||||||||||||
similarity | Contains3 tpr repeats. Belongs to the hcp beta-lactamase family. | ||||||||||||||
catalytic activ. | A beta-lactam + h(2)o = a substituted beta- amino acid. | ||||||||||||||
gene | hcpB (H. pylori) | ||||||||||||||
function | Hydrolyzes 6-aminopenicillinic acid and 7- aminocephalosporanic acid (aca) derivatives. | ||||||||||||||
Gene Ontology |
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Primary reference | The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein., Luthy L, Grutter MG, Mittl PR, J Biol Chem 2002 Mar 22;277(12):10187-93. PMID:11777911 |
Data retrieval |
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View 1KLX in 3D |
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Visual 3D analysis of 1KLX |
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Structure-derived information |
- Domain d1klxa_, region A [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
Other resources with information on 1KLX |
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