1JR0 | Toxin | date | Aug 09, 2001 ![]() |
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title | Cholera Toxin B-Pentamer With Ligand Bmsc-0011 | ||||||||||||||
authors | E.A.Merritt, W.G.J.Hol | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Cholera Toxin B Subunit Chain: D, E, F, G, H Engineered: Yes |
Organism_scientific: Vibrio Cholerae Organism_common: Bacteria Gene: Ctxb Expression_system: Escherichia Coli Expression_system_common: Bacteria | ||||||||||||||
symmetry | Space Group: C 1 2 1 | R_factor | |||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 1.30 Å | ||||||||||||
ligand | A24 | enzyme |
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similarity | Belongs to the Enterotoxin_b family. | ||||||||||||||
subunit | The a subunit contains two chains, a1 and a2, linked by a disulfide bridge. The holotoxin (choleragen) consists of a pentameric ring of b subunits whose central pore is occupied by the a subunit. | ||||||||||||||
gene | ctxB (V. cholerae) | ||||||||||||||
function | It can bind five gm1 gangliosides. The b subunit pentameric ring directs the a subunit to its target by binding to the gm1 gangliosides present on the surface of the intestinal epithelial cells. It has no toxic activity by itself. | ||||||||||||||
Gene Ontology |
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Primary reference | Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes., Pickens JC, Merritt EA, Ahn M, Verlinde CL, Hol WG, Fan E, Chem Biol 2002 Feb;9(2):215-24. PMID:11880036 |
Data retrieval |
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Visual 3D analysis of 1JR0 |
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Structure-derived information |
- Domain d1jr0d_, region D [Jmol] [rasmolscript] [script source] - Domain d1jr0e_, region E [Jmol] [rasmolscript] [script source] - Domain d1jr0f_, region F [Jmol] [rasmolscript] [script source] - Domain d1jr0g_, region G [Jmol] [rasmolscript] [script source] - Domain d1jr0h_, region H [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
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