1JI4	Metal Transport	date	Jun 29, 2001
title	Nap Protein From Helicobacter Pylori
authors	G.Zanotti, E.Papinutto, W.G.Dundon, R.Battistutta, M.Seveso, G.Del Giudice, R.Rappuoli, C.Montecucco
compound		source
Molecule: Neutrophil-Activating Protein A Chain: A, B, C, D, E, F, G, H, I, J, K, L Synonym: Nap A, Bacterioferritin Engineered: Yes		Organism_scientific: Helicobacter Pylori Organism_common: Bacteria Gene: Napa Expression_system: Bacillus Subtilis Expression_system_common: Bacteria Expression_system_vector_type: Plasmid
symmetry	Space Group: P 1 21 1	R_factor	0.215
crystal cell	length a length b length c angle alpha angle beta angle gamma 88.778 133.225 95.228 90.00 93.99 90.00
method	X-Ray Diffraction	resolution	2.52 Å
ligand	FE, MPD, UNX	enzyme
note	1JI4 is a representative structure
similarity	Belongs to the dps family.[Ferritin]
Gene	DPS (H. pylori); HP (H. pylori); NAPA (H. pylori)
function	Exhibits proadhesive activity in host cells. May perform analogous functions in iron detoxification and storage as that of animal ferritins (by similarity).
Gene Ontology	Chain Function Process Component F, A, J, K, E, B, H, C, D, I, G, L iron ion binding ferric iron binding oxidoreductase activity metal ion binding transition metal ion binding... cellular iron ion homeostasi... response to stress pathogenesis cytoplasm
Primary reference	Structure of the neutrophil-activating protein from Helicobacter pylori., Zanotti G, Papinutto E, Dundon W, Battistutta R, Seveso M, Giudice G, Rappuoli R, Montecucco C, J Mol Biol 2002 Oct 11;323(1):125-30. PMID:12368104

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (304 Kb) [Save to disk] Biological Unit Coordinates (1ji4.pdb1.gz) 301 Kb CSU: Contacts of Structural Units for 1JI4 Likely Quarternary Molecular Structure file(s) for 1JI4 Structure Factors (611 Kb) Retrieve 1JI4 in mmCIF format [Save to disk]

View 1JI4 in 3D

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Visual 3D analysis of 1JI4

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Structure-derived information

Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1JI4, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1ji4a_, region A [Jmol] [rasmolscript] [script source]     - Domain d1ji4b_, region B [Jmol] [rasmolscript] [script source]     - Domain d1ji4c_, region C [Jmol] [rasmolscript] [script source]     - Domain d1ji4d_, region D [Jmol] [rasmolscript] [script source]     - Domain d1ji4e_, region E [Jmol] [rasmolscript] [script source]     - Domain d1ji4f_, region F [Jmol] [rasmolscript] [script source]     - Domain d1ji4g_, region G [Jmol] [rasmolscript] [script source]     - Domain d1ji4h_, region H [Jmol] [rasmolscript] [script source]     - Domain d1ji4i_, region I [Jmol] [rasmolscript] [script source]     - Domain d1ji4j_, region J [Jmol] [rasmolscript] [script source]     - Domain d1ji4k_, region K [Jmol] [rasmolscript] [script source]     - Domain d1ji4l_, region L [Jmol] [rasmolscript] [script source] Fold representative 1ji4 from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1ji4_L] [1ji4_D] [1ji4_K] [1ji4_H] [1ji4_E] [1ji4_B] [1ji4_I] [1ji4_F] [1ji4_A] [1ji4_J] [1ji4_G] [1ji4_C]

Other resources with information on 1JI4

InterPro: IPR012347 , IPR002177 , IPR008331 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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