1I4X	Toxin	date	Feb 23, 2001
title	Staphylococcal Enterotoxin C2, Monoclinic Form Crystallized At Ph 8.0
authors	S.Swaminathan, M.Sax
compound		source
Molecule: Enterotoxin Type C-2 Chain: A Synonym: Sec2		Organism_scientific: Staphylococcus Aureus Organism_common: Bacteria
symmetry	Space Group: P 1 21 1	R_factor	0.207
crystal cell	length a length b length c angle alpha angle beta angle gamma 43.300 70.360 42.200 90.00 90.30 90.00
method	X-Ray Diffraction	resolution	2.40 Å
ligand	ZN	enzyme
related structures	by homologous chain: 1KLG, 1SBB
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subcellular loc.	Secreted protein.
Gene	ENTC2 (S. aureus)
function	The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene Ontology	Chain Function Process Component A zinc ion binding metal ion binding pathogenesis extracellular region
Primary reference	Structure of staphylococcal enterotoxin C2 at various pH levels., Kumaran D, Eswaramoorthy S, Furey W, Sax M, Swaminathan S, Acta Crystallogr D Biol Crystallogr 2001 Sep;57(Pt 9):1270-5. PMID:11526318

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (44 Kb) [Save to disk] Biological Unit Coordinates (1i4x.pdb1.gz) 41 Kb CSU: Contacts of Structural Units for 1I4X Likely Quarternary Molecular Structure file(s) for 1I4X Retrieve 1I4X in mmCIF format [Save to disk]

View 1I4X in 3D

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Visual 3D analysis of 1I4X

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1I4X, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1i4xa1, region A:1-120 [Jmol] [rasmolscript] [script source]     - Domain d1i4xa2, region A:121-239 [Jmol] [rasmolscript] [script source] Fold representative 1i4x from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1i4x_A]

Other resources with information on 1I4X

InterPro: IPR006123 , IPR006173 , IPR006177 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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