1I4R	Toxin	date	Feb 22, 2001
title	Crystal Structure Of Staphylococcal Enterotoxin C2 At 100k Crystallized At Ph 6.5
authors	D.Kumaran, S.Swaminathan
compound		source
Molecule: Enterotoxin Type C-2 Chain: A		Organism_scientific: Staphylococcus Aureus Organism_common: Bacteria
symmetry	Space Group: P 43 21 2	R_factor	0.201
crystal cell	length a length b length c angle alpha angle beta angle gamma 42.730 42.730 288.540 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.10 Å
ligand	ZN	enzyme
related structures	by homologous chain: 1CQV, 1PYW
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subcellular loc.	Secreted protein.
Gene	ENTC2 (S. aureus)
function	The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene Ontology	Chain Function Process Component A zinc ion binding metal ion binding pathogenesis extracellular region
Primary reference	Structure of staphylococcal enterotoxin C2 at various pH levels., Kumaran D, Eswaramoorthy S, Furey W, Sax M, Swaminathan S, Acta Crystallogr D Biol Crystallogr 2001 Sep;57(Pt 9):1270-5. PMID:11526318

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (47 Kb) [Save to disk] Biological Unit Coordinates (1i4r.pdb1.gz) 44 Kb CSU: Contacts of Structural Units for 1I4R Likely Quarternary Molecular Structure file(s) for 1I4R Structure Factors (146 Kb) Retrieve 1I4R in mmCIF format [Save to disk]

View 1I4R in 3D

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Structure-derived information

Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1I4R, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1i4ra1, region A:1-120 [Jmol] [rasmolscript] [script source]     - Domain d1i4ra2, region A:121-239 [Jmol] [rasmolscript] [script source] Fold representative 1i4r from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1i4r_A]

Other resources with information on 1I4R

InterPro: IPR006123 , IPR006173 , IPR006177 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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