1I4G | Toxin | date | Feb 21, 2001 ![]() ![]() |
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title | Crystal Structure Of Staphylococcal Enterotoxin A Mutant H187a With Reduced Zn2+ Affinity | ||||||||||||||
authors | M.Hakansson, P.Antonsson, P.Bjork, L.A.Svensson | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Enterotoxin Type A Chain: A, B Synonym: Sea Engineered: Yes Mutation: Yes |
Organism_scientific: Staphylococcus Aureus Organism_common: Bacteria Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Ul635 Expression_system_vector_type: Plasmid Expression_system_plasmid: Pkp889 | ||||||||||||||
symmetry | Space Group: P 21 21 21 | R_factor | 0.178 | ||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 2.10 Å | ||||||||||||
ligand | SO4, ZN | enzyme |
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related structures | by homologous chain: 1ESF, 1GXS, 1SXT | ||||||||||||||
similarity | Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C] | ||||||||||||||
subunit | Monomer. | ||||||||||||||
subcellular loc. | Secreted protein. | ||||||||||||||
Gene | ENTA (S. aureus) | ||||||||||||||
function | The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. | ||||||||||||||
Gene Ontology |
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Primary reference | Cooperative zinc binding in a staphylococcal enterotoxin A mutant mimics the SEA-MHC class II interaction., Hakansson M, Antonsson P, Bjork P, Svensson LA, J Biol Inorg Chem 2001 Oct;6(8):757-62. PMID:11713682 |
Data retrieval |
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View 1I4G in 3D |
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Visual 3D analysis of 1I4G |
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Structure-derived information |
- Domain d1i4ga1, region A:10-120 [Jmol] [rasmolscript] [script source] - Domain d1i4ga2, region A:121-233 [Jmol] [rasmolscript] [script source] - Domain d1i4gb2, region B:121-233 [Jmol] [rasmolscript] [script source] - Domain d1i4gb1, region B:8-120 [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
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