1HX5	Chaperone	date	Jan 11, 2001
title	Crystal Structure Of M. Tuberculosis Chaperonin-10
authors	B.Taneja, S.C.Mande, Tb Structural Genomics Consortium (Tbsgc)
compound		source
Molecule: 10 Kda Chaperonin Chain: A, B, C, D, E, F, G Synonym: Protein Cpn10 Engineered: Yes		Organism_scientific: Mycobacterium Tuberculosis Organism_common: Bacteria Gene: Rv3418c Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Jm109 Expression_system_vector_type: Plasmid Expression_system_plasmid: Pmal-C
symmetry	Space Group: C 2 2 21	R_factor	0.202
crystal cell	length a length b length c angle alpha angle beta angle gamma 77.500 162.500 125.600 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	3.50 Å
similarity	Belongs to the groes chaperonin family.[Cpn10]
subunit	Heptamer of 7 subunits arranged in a ring (by similarity).
subcellular loc.	Cytoplasm (by similarity).
gene	MT3527 (M. tuberculosis)
function	Binds to cpn60 in the presence of mg-atp and suppresses the atpase activity of the latter.
Gene Ontology	Chain Function Process Component F, A, D, C, G, E, B ATP binding unfolded protein binding protein folding response to unfolded protein...
Primary reference	Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity., Lin CH, Huang X, Kolbanovskii A, Hingerty BE, Amin S, Broyde S, Geacintov NE, Patel DJ, J Mol Biol 2001 Mar 9;306(5):1059-80. PMID:11237618

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (104 Kb) [Save to disk] Biological Unit Coordinates (1hx5.pdb1.gz) 81 Kb CSU: Contacts of Structural Units for 1HX5 Likely Quarternary Molecular Structure file(s) for 1HX5 Structure Factors (83 Kb) Retrieve 1HX5 in mmCIF format [Save to disk]

View 1HX5 in 3D

On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1HX5

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1HX5, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1hx5a_, region A [Jmol] [rasmolscript] [script source]     - Domain d1hx5b_, region B [Jmol] [rasmolscript] [script source]     - Domain d1hx5c_, region C [Jmol] [rasmolscript] [script source]     - Domain d1hx5d_, region D [Jmol] [rasmolscript] [script source]     - Domain d1hx5e_, region E [Jmol] [rasmolscript] [script source]     - Domain d1hx5f_, region F [Jmol] [rasmolscript] [script source]     - Domain d1hx5g_, region G [Jmol] [rasmolscript] [script source] Fold representative 1hx5 from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1hx5_F] [1hx5_A] [1hx5_G] [1hx5_E] [1hx5_B] [1hx5_C] [1hx5_D]

Other resources with information on 1HX5

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