1F0N | Transferase | date | May 16, 2000 ![]() |
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title | Mycobacterium Tuberculosis Antigen 85b | ||||||||||||||
authors | D.H.Anderson, G.Harth, M.A.Horwitz, D.Eisenberg, Tb Structural Genomics Consortium (Tbsgc) | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Antigen 85b Chain: A Engineered: Yes |
Organism_scientific: Mycobacterium Tuberculosis Organism_common: Bacteria Expression_system: Mycobacterium Smegmatis Expression_system_common: Bacteria Expression_system_plasmid: Psmt3 | ||||||||||||||
symmetry | Space Group: P 31 2 1 | R_factor | |||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 1.80 Å | ||||||||||||
ligand | MES, MPD | enzyme |
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similarity | Belongs to the mycobacterial a85 antigen family.[Esterase] | ||||||||||||||
subcellular loc. |
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genes | MT1934, fbpB (M. tuberculosis) | ||||||||||||||
function | Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity. | ||||||||||||||
Gene Ontology |
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Primary reference | An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase., Anderson DH, Harth G, Horwitz MA, Eisenberg D, J Mol Biol 2001 Mar 23;307(2):671-81. PMID:11254389 |
Data retrieval |
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View 1F0N in 3D |
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Visual 3D analysis of 1F0N |
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Structure-derived information |
- Domain d1f0na_, region A [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
Other resources with information on 1F0N |
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