1ESF	Enterotoxin	date	May 25, 1995
title	Staphylococcal Enterotoxin A
authors	E.M.Schad, L.A.Svensson
compound		source
Molecule: Staphylococcal Enterotoxin A Chain: A, B Engineered: Yes		Organism_scientific: Staphylococcus Aureus Expression_system: Escherichia Coli
symmetry	Space Group: P 1 21 1	R_factor	0.204
crystal cell	length a length b length c angle alpha angle beta angle gamma 53.600 62.500 75.100 90.00 96.00 90.00
method	X-Ray Diffraction	resolution	1.90 Å
ligand	CD	enzyme
related structures	by homologous chain: 1DYQ, 1I4G
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subunit	Monomer.
subcellular loc.	Secreted protein.
Gene	ENTA (S. aureus)
function	The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene Ontology	Chain Function Process Component A, B zinc ion binding metal ion binding pathogenesis extracellular region
Primary reference	Crystal structure of the superantigen staphylococcal enterotoxin type A., Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA, EMBO J 1995 Jul 17;14(14):3292-301. PMID:7628431

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (82 Kb) [Save to disk] Biological Unit Coordinates (1esf.pdb1.gz) 43 Kb Biological Unit Coordinates (1esf.pdb2.gz) 39 Kb CSU: Contacts of Structural Units for 1ESF Likely Quarternary Molecular Structure file(s) for 1ESF Structure Factors (438 Kb) Retrieve 1ESF in mmCIF format [Save to disk]

View 1ESF in 3D

Proteopedia, because life has more than 2D. On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1ESF

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Structure-derived information

Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1ESF, from MSDmotif at EBI Genome occurence of 1ESF's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1esfa1, region A:1-120 [Jmol] [rasmolscript] [script source]     - Domain d1esfa2, region A:121-233 [Jmol] [rasmolscript] [script source]     - Domain d1esfb1, region B:1-120 [Jmol] [rasmolscript] [script source]     - Domain d1esfb2, region B:121-233 [Jmol] [rasmolscript] [script source] Fold representative 1esf from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1esf_B] [1esf_A]

Other resources with information on 1ESF

InterPro: IPR006123 , IPR006173 , IPR006177 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

Movements, Movies and Images

Domain movements in 1ESF from the Database of Macromolecular Movements. Images from IMB Jena Image Library of Biological Macromolecules.

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