1DQY	Immune System	date	Jan 05, 2000
title	Crystal Structure Of Antigen 85c From Mycobacterium Tuberculosis With Diethyl Phosphate Inhibitor
authors	D.R.Ronning, T.Klabunde, J.C.Sacchettini, Tb Structural Genomics Consortium (Tbsgc)
compound		source
Molecule: Antigen 85-C Chain: A Synonym: 85c		Organism_scientific: Mycobacterium Tuberculosis Organism_common: Bacteria
symmetry	Space Group: C 1 2 1	R_factor	0.168
crystal cell	length a length b length c angle alpha angle beta angle gamma 128.800 67.808 39.765 90.00 102.73 90.00
method	X-Ray Diffraction	resolution	1.83 Å
ligand	DEP, MPD	enzyme
similarity	Belongs to the mycobacterial a85 antigen family.[Esterase]
subcellular loc.	Secreted protein.
function	Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.
Gene Ontology	Chain Function Process Component A acyltransferase activity transferase activity
Primary reference	Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines., Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC, Nat Struct Biol 2000 Feb;7(2):141-6. PMID:10655617

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (61 Kb) [Save to disk] Biological Unit Coordinates (1dqy.pdb1.gz) 51 Kb CSU: Contacts of Structural Units for 1DQY Likely Quarternary Molecular Structure file(s) for 1DQY Retrieve 1DQY in mmCIF format [Save to disk]

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1DQY, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1dqya_, region A [Jmol] [rasmolscript] [script source] Fold representative 1dqy from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1dqy_A]

Other resources with information on 1DQY

InterPro: IPR000801 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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