1C79 | Hydrolase | date | Feb 01, 2000 ![]() ![]() |
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title | Staphylokinase (Sak) Dimer | ||||||||||||||
authors | Z.Rao, F.Jiang, Y.Liu, X.Zhang, Y.Chen, M.Bartlam, H.Song, Y.Ding | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Staphylokinase Chain: A, B Synonym: Sak Ec: 3.4.24.29 Engineered: Yes |
Organism_scientific: Staphylococcus Aureus Organism_common: Bacteria Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_plasmid: Vpet-11 | ||||||||||||||
symmetry | Space Group: P 21 21 21 | R_factor | 0.198 | ||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 2.30 Å | ||||||||||||
ligand | enzyme | Aureolysin;. Staphylococcus aureus neutral proteinase;. Staphylococcus aureus neutral protease. Hydrolase E.C.3.4.24.29 BRENDA | |||||||||||||
related structures | by homologous chain: 1BUI, 1C76, 1C77, 1C78 | ||||||||||||||
similarity | Belongs to the Staphylokinase family. | ||||||||||||||
subcellular loc. | Secreted protein. | ||||||||||||||
Gene | SAK (S. aureus) | ||||||||||||||
function | Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1. 1 complex with plasmin, which in turn activates other plasminogen molecules. | ||||||||||||||
Gene Ontology |
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Primary reference | Crystal structure of a staphylokinase: variant a model for reduced antigenicity., Chen Y, Song G, Jiang F, Feng L, Zhang X, Ding Y, Bartlam M, Yang A, Ma X, Ye S, Liu Y, Tang H, Song H, Rao Z, Eur J Biochem 2002 Jan;269(2):705-11. PMID:11856331 |
Data retrieval |
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View 1C79 in 3D |
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Visual 3D analysis of 1C79 |
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Structure-derived information |
- Domain d1c79a_, region A [Jmol] [rasmolscript] [script source] - Domain d1c79b_, region B [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
Other resources with information on 1C79 |
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