1C77	Hydrolase	date	Feb 01, 2000
title	Staphylokinase (Sak) Dimer
authors	Z.Rao, F.Jiang, Y.Liu, X.Zhang, Y.Chen, M.Bartlam, H.Song, Y.Ding
compound		source
Molecule: Staphylokinase Chain: A, B Synonym: Sak Ec: 3.4.24.29 Engineered: Yes		Organism_scientific: Staphylococcus Aureus Organism_common: Bacteria Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_plasmid: Vpet-11
symmetry	Space Group: P 21 21 21	R_factor	0.198
crystal cell	length a length b length c angle alpha angle beta angle gamma 43.870 59.260 102.420 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.30 Å
ligand		enzyme	Aureolysin;. Staphylococcus aureus neutral proteinase;. Staphylococcus aureus neutral protease. Hydrolase E.C.3.4.24.29 BRENDA
related structures	by homologous chain: 1C78, 1C79
similarity	Belongs to the Staphylokinase family.
subcellular loc.	Secreted protein.
Gene	SAK (S. aureus)
function	Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1. 1 complex with plasmin, which in turn activates other plasminogen molecules.
Gene Ontology	Chain Function Process Component A, B plasminogen activator activi...
Primary reference	Crystal structure of a staphylokinase: variant a model for reduced antigenicity., Chen Y, Song G, Jiang F, Feng L, Zhang X, Ding Y, Bartlam M, Yang A, Ma X, Ye S, Liu Y, Tang H, Song H, Rao Z, Eur J Biochem 2002 Jan;269(2):705-11. PMID:11856331

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (42 Kb) [Save to disk] Biological Unit Coordinates (1c77.pdb1.gz) 39 Kb CSU: Contacts of Structural Units for 1C77 Likely Quarternary Molecular Structure file(s) for 1C77 Retrieve 1C77 in mmCIF format [Save to disk]

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1C77, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1c77a_, region A [Jmol] [rasmolscript] [script source]     - Domain d1c77b_, region B [Jmol] [rasmolscript] [script source] Fold representative 1c77 from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1c77_A] [1c77_B]

Other resources with information on 1C77

InterPro: IPR004093 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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