1C76	Hydrolase	date	Feb 01, 2000
title	Staphylokinase (Sak) Monomer
authors	Z.Rao, F.Jiang, Y.Liu, X.Zhang, Y.Chen, M.Bartlam, H.Song, Y.Ding
compound		source
Molecule: Staphylokinase Chain: A Synonym: Sak Ec: 3.4.24.29 Engineered: Yes		Organism_scientific: Staphylococcus Aureus Organism_common: Bacteria Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_vector: Vpet-11
symmetry	Space Group: C 2 2 21	R_factor	0.201
crystal cell	length a length b length c angle alpha angle beta angle gamma 43.920 59.840 102.880 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.25 Å
ligand		enzyme	Aureolysin;. Staphylococcus aureus neutral proteinase;. Staphylococcus aureus neutral protease. Hydrolase E.C.3.4.24.29 BRENDA
related structures	by homologous chain: 1C79, 2SAK
similarity	Belongs to the Staphylokinase family.
subcellular loc.	Secreted protein.
Gene	SAK (S. aureus)
function	Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1. 1 complex with plasmin, which in turn activates other plasminogen molecules.
Gene Ontology	Chain Function Process Component A plasminogen activator activi...

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (24 Kb) [Save to disk] Biological Unit Coordinates (1c76.pdb1.gz) 40 Kb CSU: Contacts of Structural Units for 1C76 Likely Quarternary Molecular Structure file(s) for 1C76 Retrieve 1C76 in mmCIF format [Save to disk]

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1C76, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1c76a_, region A [Jmol] [rasmolscript] [script source] Fold representative 1c76 from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1c76_A]

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