1BY9 | Transcription Regulation | date | Oct 27, 1998 ![]() ![]() |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
title | Crystal Structure Of The E2 Dna-Binding Domain From Human Papillomavirus Type-16: Implications For Its Dna Binding- Site Selection Mechanism | ||||||||||||||
authors | R.S.Hegde, E.J.Androphy | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Regulatory Protein E2 Chain: A Fragment: Dna-Binding Domain Engineered: Yes |
Organism_scientific: Human Papillomavirus Type 16 Cell_line: Bl21 Gene: E2 Expression_system: Escherichia Coli Expression_system_strain: Bl21 (De3) Expression_system_plasmid: Bl21 | ||||||||||||||
symmetry | Space Group: P 31 2 1 | R_factor | 0.195 | ||||||||||||
crystal cell |
| ||||||||||||||
method | X-Ray Diffraction | resolution | 2.20 Å | ||||||||||||
note | 1BY9 is a representative structure | ||||||||||||||
related structures | by homologous chain: 1A7G | ||||||||||||||
similarity | Belongs to the papillomaviruses e2 protein family.[PPV_E2_C] | ||||||||||||||
subunit | Binds dna as a dimer. | ||||||||||||||
subcellular loc. | Nucleus. | ||||||||||||||
Gene | E2 (H. papillomavirus) | ||||||||||||||
function | The e1-e2 complex binds to the origin of dna replication. It can either activate or repress transcription depending on e2re's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. E2 regulates viral transcription and dna replication. It binds to the e2re response element (5'-accnnnnnnggt-3') present in multiple copies in the regulatory region. | ||||||||||||||
Gene Ontology |
| ||||||||||||||
Primary reference | Crystal structure of the E2 DNA-binding domain from human papillomavirus type 16: implications for its DNA binding-site selection mechanism., Hegde RS, Androphy EJ, J Mol Biol 1998 Dec 18;284(5):1479-89. PMID:9878365 |
Data retrieval |
![]() |
View 1BY9 in 3D |
![]() |
Visual 3D analysis of 1BY9 |
|
Structure-derived information |
- Domain d1by9__, region [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
Other resources with information on 1BY9 |
Movements, Movies and Images |