1BSO	Transport Protein	date	Aug 29, 1998
title	12-Bromododecanoic Acid Binds Inside The Calyx Of Bovine Beta-Lactoglobulin
authors	B.Y.Qin, L.K.Creamer, E.N.Baker, G.B.Jameson
compound		source
Molecule: Bovine Beta-Lactoglobulin A Chain: A		Organism_scientific: Bos Taurus Organism_common: Bovine Variant: Variant A Organ: Breast Tissue: Mammary Gland Secretion: Milk
symmetry	Space Group: P 32 2 1	R_factor	0.234
crystal cell	length a length b length c angle alpha angle beta angle gamma 54.026 54.026 112.183 90.00 90.00 120.00
method	X-Ray Diffraction	resolution	2.23 Å
ligand	BRC	enzyme
similarity	Belongs to the Lipocalin family.
subunit	Under physiological conditions beta-lactoglobulin exists as an equilibrium mixture of monomeric and dimeric forms.
post-translat. modifications	Alternate disulfide bonds occur in equal amounts in all variants examined.
tissue	Synthesized in mammary glound and secreted in milk.
subcellular loc.	Secreted protein.
gene	LGB (B. taurus)
function	Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
Gene Ontology	Chain Function Process Component A transporter activity binding retinol binding transport type I hypersensitivity
Primary reference	12-Bromododecanoic acid binds inside the calyx of bovine beta-lactoglobulin., Qin BY, Creamer LK, Baker EN, Jameson GB, FEBS Lett 1998 Nov 6;438(3):272-8. PMID:9827560

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (38 Kb) [Save to disk] Biological Unit Coordinates (1bso.pdb1.gz) 56 Kb CSU: Contacts of Structural Units for 1BSO Likely Quarternary Molecular Structure file(s) for 1BSO Structure Factors (158 Kb) Retrieve 1BSO in mmCIF format [Save to disk]

View 1BSO in 3D

On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1BSO

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Structure-derived information

Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1BSO, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1bsoa_, region A [Jmol] [rasmolscript] [script source] Fold representative 1bso from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1bso_A]

Other resources with information on 1BSO

InterPro: IPR002345 , IPR002447 , IPR000566 , IPR012674 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

Movements, Movies and Images

Domain movements in 1BSO from the Database of Macromolecular Movements. Images from IMB Jena Image Library of Biological Macromolecules.

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