Dataset or this study was taken from research article "Quantifying the chemical beauty of drugs". We got this dataset from G. Richard Bickertonon and Andrew L. Hopkins on request. This dataset consist of 771 oral drugs taken from ChEMBL Drug store database. Based on this a ADS were derived and Second dataset called benchmarking dataset consist of 771 oral drug taken as positive from DrugBank database and 10250 compounds from PDB database considered as negative. Due to the error in descriptor calculation of 5 molecules, our negative dataset consist of 10245 compounds.