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IDSequenceNameNature of peptide or cargoAssayTissue permeabilityTissue SamplePUBMED ID
1301SYSMEHFRWGKPVα-Melanocyte stimulating hormone (MSH)Controls pigmentary changes in many vertebrates and melanin synthesis within epidermal melanocytes is responsible for melanin pigmentation of the skin, hair, and feathers in man, birds and other mammals.Light and electron microscopy10-7 and 10-8 concentrations turned yellow hair brownMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect3684299
1302SYS-Nle-EHfRWGKPV[Nle4, D-Phe7]-alpha-MSHThe analogue is superpotent, being 10- 1000 times more active than the native hormoneLight and electron microscopy10-7 to 10-12 concentrations turned yellow hair brownMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect3684299
1303Nle-EHfRWGK[Nle4, D-Phe7]-alpha-MSH4-11Not mentionedLight and electron microscopy10-8 to 10-14 concentrations turned yellow hair brownMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect3684299
1304Nle-EHfRWG[Nle4, D-Phe7]-alpha-MSH4-10Not mentionedLight and electron microscopy10-8 to 10-14 concentrations turned yellow hair brownMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect3684299
1305SYSMEHFRWGKPVAlpha-MSH (melanocyte-stimulating hormone)Stimulates melanogenesisElectron microscopy and Light microscopyConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application.dorsal trunk of mice (C57BL/6JA y)3624899
1306SYS-Nle-EHfRWGKPV(Nle4, D-Phe7]-α-MSHthe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of miceElectron microscopy and Light microscopyConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application.dorsal trunk of mice (C57BL/6JA y)3624899
1307Nle-EHfFRWGKAc-[Nle4, D-Phe7]-α- MSH4–11-NH2the melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of miceElectron microscopy and Light microscopyConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application.dorsal trunk of mice (C57BL/6JA y)3624899
1308Nle-EH-FRWGAc-[Nle4, D-Phe7]-α-MSH4–10-NH2the melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of miceElectron microscopy and Light microscopyConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application.dorsal trunk of mice (C57BL/6JA y)3624899
1309SYSMEHFRWGKPVα-Melanocyte stimulating hormone (MSH)Controls pigmentary changes in many vertebrates and melanin synthesis within epidermal melanocytes is responsible for melanin pigmentation of the skin, hair, and feathers in man, birds and other mammals.Electron microscopic examinationMinimal effective dose=10-8to10-9M. It stimulated eumelanogenesis in all hair emerging from the areas previously plucked.Posterior dorsum of mice (C57BL/6JA y)3573985
1310SYS-Nle-EHfRWGKPV(Nle4, D-Phe7)-a-MSHThe analogue is superpotent, being 10- 1000 times more active than the native hormoneElectron microscopic examinationMinimal effective dose=10-12M. It is transdermally delivered systemically to hair follicles throughout the body to induce follicular melanogenesis. Microscopic examination revealed eumelanin within hair bulbs by 24 hours after topical application of the analogue.Posterior dorsum of mice (C57BL/6JA y)3573985
1311SYS-Nle-EHfRWGKPV[Nle4, D-Phe7]-alpha-MSHA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes.Frog Skin BioassayPercent positive samples of transdermal delivery :65% (15/23)Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation2845208
1312SYS-Nle-EHfRWGKPV[Nle4, D-Phe7]-alpha-MSHA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes.RadioimmunoassayPercent positive samples of transdermal delivery :85% (11/13)Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation2845208
1313SYS-Nle-EHfRWGKPV[Nle4, D-Phe7]-alpha-MSHA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes.Frog Skin BioassayPercent positive samples of transdermal delivery :6.6% (1/15)Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of mature Sprague Dawley rats.2845208
1314SYS-Nle-EHfRWGKPV[Nle4, D-Phe7]-alpha-MSHA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes.RadioimmunoassayPercent positive samples of transdermal delivery :11.8% (2/17)Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of mature Sprague Dawley rats.2845208
1315SYS-Nle-EHfRWGKPV[Nle4, D-Phe7]-alpha-MSHA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes.Frog Skin Bioassay, radioimmunoassay and microscopyTransdermal delivery of 0.05%Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation2845208
1316SYS-Nle-EHfRWGKPV[Nle4, D-Phe7]-alpha-MSHA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes.Frog Skin Bioassay, radioimmunoassay and microscopyTransdermal delivery of 0.08%Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation2845208
1317SYSMEHFRWGKPVα-Melanocyte stimulating hormone (MSH)It acts as an antagonist to interleukin 1 (IL-1) bioactivities such as inhibition of fever production, thymocyte proliferation, and inhibition of release of acute phase inflammatory molecules from the liver.Indirect immunoperoxidase and indirect immunofluorescence stainingPhenotypic markers: Ia=408 ± 19 , Thy1.2=340 ± 15 and Asialo GM-1=465 ± 18Dorsal surface of the ear of five to seven-wk-old male C57BL/6 (H-2b) mice 2550560
1318TSEKSQTPLVTLdes-enkephalin-ƴ-endorphin(DEƴE)A highly potent neuropeptide which has been implicated in schizophrenic psychosesRadioactive assayPermeability coefficient:86±30*105 cm/hour, flux of radiolabelled material: 1130±400*1012 mol/hour/cm2Deglycerinized human cadaver skin2533571
1319TSEKSQTPLVTLdes-enkephalin-ƴ-endorphin(DEƴE)A highly potent neuropeptide which has been implicated in schizophrenic psychosesRadioactive assayPermeability coefficient:1.2±0.4*105 cm/hour, flux of radiolabelled material: 1.1±0.4*1012 mol/hour/cm2Human stratum corneum2533571
1320TSEKSQTPLVTLdes-enkephalin-ƴ-endorphin(DEƴE)A highly potent neuropeptide which has been implicated in schizophrenic psychosesRadioactive assayPermeability coefficient:1.9*105 cm/hour, flux of radiolabelled material:2.7*1012 mol/hour/cm2Human stratum corneum2533571
1321TSEKSQTPLVTLdes-enkephalin-ƴ-endorphin(DEƴE)A highly potent neuropeptide which has been implicated in schizophrenic psychosesRadioactive assayPermeability coefficient:4.7*105 cm/hour, flux of radiolabelled material:4.2*1012 mol/hour/cm2Human stratum corneum2533571
1322A-isoGln-AMuramyl tripeptide-phosphatidylethanolamine (MTP-PE, CGP 19835)MTP-PE is a stimulator of innate immunity and a synthetic molecule derived from muramyl dipeptide (MDP). MTP-PE results from the covalent addition of alanin and dipalmitoyl phosphatidyl ethanolamine to MDP , which is a peptidoglycan found in Gram-positive and Gram-negative bacterial cell walls.Plaque reduction assay using calf kidney cellsInitial symptomatology to Herpes simplex 2/Angelotti is milder, the local disease is significantly mitigated by MTP-PE (P≤ 0.05). Recovery is accelerated and animal becomes asymptomatic by day 15-20.Tif:DHP Dunking-Hartley Pirbright guinea pigs. After slight abrasion of the vaginal mucosa, a piece of fibrin foam impregnated with virus suspension was introduced into the vagina.2433236
1323A-isoGln-AMuramyl tripeptide-phosphatidylethanolamine (MTP-PE, CGP 19835)MTP-PE is a stimulator of innate immunity and a synthetic molecule derived from muramyl dipeptide (MDP). MTP-PE results from the covalent addition of alanin and dipalmitoyl phosphatidyl ethanolamine to MDP , which is a peptidoglycan found in Gram-positive and Gram-negative bacterial cell walls.Plaque reduction assay using calf kidney cellsInitial symptomatology to Herpes simplex 2/Alabama is milder, the local disease is significantly mitigated by MTP-PE (P≤ 0.05). Recovery is accelerated and animal becomes asymptomatic by day 15-20.Tif:DHP Dunking-Hartley Pirbright guinea pigs. After slight abrasion of the vaginal mucosa, a piece of fibrin foam impregnated with virus suspension was introduced into the vagina.2433236
1324A-isoGln-AMuramyl tripeptide-phosphatidylethanolamine (MTP-PE, CGP 19835)MTP-PE is a stimulator of innate immunity and a synthetic molecule derived from muramyl dipeptide (MDP). MTP-PE results from the covalent addition of alanin and dipalmitoyl phosphatidyl ethanolamine to MDP , which is a peptidoglycan found in Gram-positive and Gram-negative bacterial cell walls.Plaque reduction assay using calf kidney cellsInitial symptomatology to Herpes simplex 2/MS is milder, the local disease is significantly mitigated by MTP-PE (P≤ 0.05). Recovery is accelerated and animal becomes asymptomatic by day 15-20.Tif:DHP Dunking-Hartley Pirbright guinea pigs. After slight abrasion of the vaginal mucosa, a piece of fibrin foam impregnated with virus suspension was introduced into the vagina.2433236
1399TCapsaicinCapsaicin, the pungent ingredient of red peppers, when applied into the nasal mucosa induces violent sneezing, vasodilation and increases vascular permeability.Visual analogue scale method was used to measure burning and painful sensation on application of capsaicin.The application of capsaicin into the human nasal mucosa was immediately followed by a painful sensation that was described by all the subjects as burning. A variable number of sneezes (from I up to 8) also occurred.Human nasal mucosa3370386
1400TCapsaicinCapsaicin activates sensory nerve endings in the nose and the paranasal sinuses, thereby stimulating protective reflexes involved in sneezing and in increased vasopermeability and stimulate mucociliary activityThe amount of nasal mucosa secreted in response to capsaicin was weighed.Capsaicin stimulated the secretion of nasal fluid in a dose-dependent manner when administered as a single dose.Nasal mucosa of rats2480171
1402(Chain A: GIVEQCCTSICSLYQLENYCN)
(Chain B: FVNQHLCGSHLVEALYLVCGERGFFYTPKT)
InsulinInsulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.Chloride in the sweat determined by titration with a Cotiove chloridometerControl/Cystic fibrosis patients: 14.81±2.39/79.70±3.59(Vehicle treated) and 14.47±2.66/68.07±3.29(Insulin treated)Stratum corneum of arm of cystic fibrosis patients1144451
1403(Chain A: GIVEQCCTSICSLYQLENYCN)
(Chain B: FVNQHLCGSHLVEALYLVCGERGFFYTPKT)
InsulinInsulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.Chloride in the sweat determined by titration with a Cotiove chloridometerControl/Cystic fibrosis patients: 14.81±2.39/16.03±2.34(Vehicle treated) and 14.47±2.66/11.52±1.28(Insulin treated)Stratum corneum of arm of cystic fibrosis patients1144451
1405rPKPQQwFwLLSpantideEffectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury.Radioimmunoassay, HPLCSystemic uptake corresponds to a serum concentration peak of 4.5*10-9M after 15 minutesLeft eye of pigmented rabbits of either sex and weighing 2-3 kg1689665
1406rPKPQQwFwLLSpantideEffectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury.Radioimmunoassay, HPLCSystemic uptake corresponds to a serum concentration peak of 1*10-8M after 15 minutes and intraoccular uptake corresponded to a plateau at 140-150ng/ml for 1-3 hours after completion of applicationLeft eye of pigmented rabbits of either sex and weighing 2-3 kg1689665
1407rPKPQQwFwLLSpantideEffectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury.Radioimmunoassay, HPLCSystemic uptake corresponds to a serum concentration peak of 1*10-7M after 15 minutes and intraoccular uptake corresponded to a plateau at 1.3-1.5µg/ml for 90-240 minutes after completion of application giving an approximate concentration of 10m6 M in the aqueous humor.Left eye of pigmented rabbits of either sex and weighing 2-3 kg1689665
1436ACDTATCVTHRLAGL
LSRSGGVVKNNFVPT
NVGSKAF
α-CGRP (α-calcitonin gene-related peptide)Specific binding sites for CGRP have been demonstrated both in the brain and in peripheral target tissues, where CGRP has been shown to act through a CAMP-dependent mechanismIntraocular pressure (IOP) calculated electromanometrically, blood-aqueous barrier, pupil size, blood pressure and cyclic AMP (CAMP) content in the aqueous humour of rabbits via 125I-radioimmunoassayIOP:Control=1.8mmHg, Neutral formaldehyde=From the baseline of 16.9±1.5 it rose by 27.3±3.8mmHg in 15.1±1.8 minutes, CGRP(0.5µg)=From the baseline of 18.5±1.1 it rose by 11.8±2.3mmHg in 15.0±2 minutes; Mean arterial blood pressure:Control=94±12/101±10(before), Formaldehyde=92±5/95±3(before), CGRP=94±5/98±4(before); cAMP after 30 minutes:Control=16.3±3.6pmol/ml, Formaldehyde right eye=88.5±35pmol/ml, Formaldehyde left eAlbino rabbits of both sexes weighing 2.2-3.1 kg were used. Right eye=Contralateral eye and left eye=Experimental.2842178
1437ACDTATCVTHRLAGL
LSRSGGVVKNNFVPT
NVGSKAF
α-CGRP (α-calcitonin gene-related peptide)Specific binding sites for CGRP have been demonstrated both in the brain and in peripheral target tissues, where CGRP has been shown to act through a CAMP-dependent mechanismIntraocular pressure (IOP) calculated electromanometrically, blood-aqueous barrier, pupil size, blood pressure and cyclic AMP (CAMP) content in the aqueous humour of rabbits via 125I-radioimmunoassayIOP:Control=1.8mmHg, Neutral formaldehyde=From the baseline of 16.9±1.5 it rose by 27.3±3.8mmHg in 15.1±1.8 minutes, CGRP(2.0µg)=From the baseline of 17.5±0.9 it rose by 19.3±3.6mmHg in 6.3±1.5 minutes; Mean arterial blood pressure:Control=94±12/101±10(before), Formaldehyde=92±5/95±3(before), CGRP=85±6/104±5(before); cAMP after 30 minutes:Control=16.3±3.6pmol/ml, Formaldehyde right eye=88.5±35pmol/ml, Formaldehyde leftAlbino rabbits of both sexes weighing 2.2-3.1 kg were used. Right eye=Contralateral eye and left eye=Experimental.2842178
1444YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationFluid: Tears- intact peptide=800pmoles/ml fluid, degraded peptide=2250pmoles/ml fluid, Percent of recovered enkephalin attributable to degradation products=33.7%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1445YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationFluid: Tears- intact peptide=250pmoles/ml fluid, degraded peptide=500pmoles/ml fluid, Percent of recovered enkephalin attributable to degradation products=59%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1446YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Conjunctiva- intact peptide=135pmoles/g tissue, degraded peptide=172pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=76.7%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1447YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Conjunctiva- intact peptide=175pmoles/g tissue, degraded peptide=185pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=85%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1448YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Conjunctiva- intact peptide=180pmoles/g tissue, degraded peptide=230pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=81.7%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1449YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Corneal epithelium- intact peptide=270pmoles/g tissue, degraded peptide=300pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=86.1%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1450YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Corneal epithelium- intact peptide=655pmoles/g tissue, degraded peptide=710pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=91.6%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1451YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Corneal epithelium- intact peptide=885pmoles/g tissue, degraded peptide=1120pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=72.1%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1452YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Corneal stroma- intact peptide=28pmoles/g tissue, degraded peptide=31pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=87.9%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1453YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Corneal stroma- intact peptide=81pmoles/g tissue, degraded peptide=92pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=84.2%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1454YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Corneal stroma- intact peptide=37.5pmoles/g tissue, degraded peptide=48pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=96.6%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1455YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Iris-Ciliary Body- intact peptide=5.2pmoles/g tissue, degraded peptide=6.5pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=81.0%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1456YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Iris-Ciliary Body- intact peptide=8.3pmoles/g tissue, degraded peptide=9pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=98.1%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1457YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationTissue: Iris-Ciliary Body- intact peptide=4.8pmoles/g tissue, degraded peptide=5.5pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=96.8%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1458YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationFluid: Aqueous humor- intact peptide=0.75pmoles/ml fluid, degraded peptide=0.9pmoles/ml fluid, Percent of recovered enkephalin attributable to degradation products=93.8%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1459YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationFluid: Aqueous humor- intact peptide=5.4pmoles/ml fluid, degraded peptide=5.7pmoles/ml fluid, Percent of recovered enkephalin attributable to degradation products=99.0%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119
1460YGGFLLeucine enkephalinLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.Radioactive determinationFluid: Aqueous humor- intact peptide=5.0pmoles/ml fluid, degraded peptide=5.24pmoles/ml fluid, Percent of recovered enkephalin attributable to degradation products=99.4%Superior limbus of both eyes of each male, albino New Zealand rabbits3503119