Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID | Sequence | Name | Nature of peptide or cargo | Assay | Tissue permeability | Tissue Sample | PUBMED ID |
|---|---|---|---|---|---|---|---|
| 1009 | RRRRRRRRRRRLILV LLAI | 11R-No. 10 | Melanogenesis inhibitory peptide | Confocal microscope | When TMR-11R was topically applied for 24 h, the signals were only observed on the surface of the skin. In contrast, 12 h later, strong signals were detected showing that TMR-11R had arrived at the skin basal layer. Moreover, 24 and 48 hours later, the signals had spread out more and were stronger in both epidermis and dermis | Skin from the back of a brown guinea pig | 24602570 |
| 1016 | GKKKKKKKRRRRRRRR | R16 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 21.43 ± 1.32 , Q48 (mg) 856.29 ± 39.50 Drug content in skin (mg/cm2) 151 ± 4.64 | Human epidermal skin | 24134794 |
| 1017 | GKKKKKKKRRRRRRRR | R16 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 23.46 ± 2.04 , Q48 (mg) 1106.03 ± 53.80 Drug content in skin (mg/cm2) 155 ± 4.85 | Human epidermal skin | 24134794 |
| 1018 | GKKKKKKKRRRRRRRR | R16 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 27.16 ± 2.65, Q48 (mg) 1256.61 ± 55.70, Drug content in skin (mg/cm2) 156 ± 6.26 | Human epidermal skin | 24134794 |
| 1023 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | TP could not pass through the skin due to the charge repulsion effect between the negative charge of the TP and the negative charge of the skin | Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1024 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts0.10± 0.01 µg/cm2 and fluxes 0.60 ± 0.06 µg/cm2·h | Acceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1025 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts 0.31 ± 0.04 µg/cm2 and fluxes 1.86 ± 0.24 µg/cm2·h | Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1026 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts 1.02 ± 0.05 µg/cm2 and fluxes 6.13± 0.28 µg/cm2·h | Acceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1027 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts 4.29 ± 0.40 µg/cm2 and fluxes 25.73 ± 2.40 µg/cm2·h | Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1077 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell, HPLC | Cumulative amounts 0.20 ± 0.05 mg/cm2 and fluxes 0.20 ± 0.05 mg/cm2·h | Viable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | 22564052 |
| 1078 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell, HPLC | Cumulative amounts 0.43 ± 0.04 mg/cm2 and fluxes 0.14 ± 0.01 mg/cm2·h | Viable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | 22564052 |
| 1079 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell, HPLC | Cumulative amounts 0.59 ± 0.12 mg/cm2 and fluxes 0.10 ± 0.02 mg/cm2·h | Viable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | 22564052 |
| 1083 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | Franz diffusion cell system, HPLC with photodiode array detector | 2-fold higher | Porcine ear skin | 22306174 |
| 1084 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | Franz diffusion cell system, HPLC with photodiode array detector | 2.8 wt% of the initial amount | Porcine ear skin | 22306174 |
| 1085 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | The scotch tape method | 0.35 wt% of Na-DFC | SC skin | 22306174 |
| 1086 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | The scotch tape method | 0.72 wt% of Na-DFC | SC skin | 22306174 |
| 1087 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | The scotch tape method | 0.3 wt% of Na-DFC | E + D skin | 22306174 |
| 1088 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | The scotch tape method | 0.57 wt% of Na-DFC | E + D skin | 22306174 |
| 1104 | KWLNALLHHGLNCAK GVLA | HG1 | Antimicrobial | Confocal microscopy, HPLC | Significant permeability of the peptide can be seen in confocal images | ICR mice skin | 21220538 |
| 1105 | ACSSSPSKHCGGRRR RRRRR | TD1-R8 | MITF-siRNA inhibition of melanin synthesis and melanoma cell apoptosis. | Laser scanning confocal microscopy | Significant penetration of carboxyfluorescein-labeled MITF-siR can be seen in confocal images of whole epidermis and partial dermis | Hair shaved back of BALB/c mice | 21119619 |
| 1106 | ACSSSPSKHCGGRRR RRRRR | TD1-R8 | MITF-siRNA inhibition of melanin synthesis and melanoma cell apoptosis. | Real-time PCR | The cream penetrated the mouse skin and mouse skin exhibited a 52% and 34% decrease in MITF and TYR mRNA levels, respectively (versus naive control). | Hair shaved back of BALB/c mice | 21119619 |
| 1108 | RALARALARALRALAR | RALA | Based on a family of amphipatic peptides that exhibit improved membrane permeability belongs to a synthetic family of CPEs. | Franz diffusion cell, HPLC | 60% of applied dose | Stratum corneum of ear of porcine | 20189781 |
| 1114 | FLGGLIKIVPAMICA VTKKC | Ranalexin | Antimicrobial | Franz diffusion cell | In combination these compounds reduced viable bacteria by 2.83 ± 0.26 log10 CFU | Abdominal skin from a 38-year-old white female donor | 19709343 |
| 1115 | FLGGLIKIVPAMICA VTKKC | Ranalexin | Antimicrobial | Franz diffusion cell | Ranalexin (100 mg l-1) reduced viable MRSA252 by 0.13 ± 0.06 log10 CFU | Abdominal skin from a 38-year-old white female donor | 19709343 |
| 1140 | TRWYSMKKTTMKIIP FNRL | Haptide | Improve the cell penetration and subsequent presentation of the antigen. | Anti-LT antibodies determination by ELISA | Significant increase in antibody titer (anti-LT) in the serum of mice on topical application with HR-gp100H | Ears of BALB/c mice | 17493711 |
| 1188 | CGSGVRGDFGSLAPR VARQL | Peptide 141–159 from the VP1 protein of serotype A12 | Elicits virus neutralising antibodies in mice after transcutaneous immunisation | ELISA | Log10 antibody titres=2.7 after first booster | Abdominal skin of BALB/c mice | 15734548 |
| 1189 | CGSGVRGDFGSLAPR VARQL | Peptide 141–159 from the VP1 protein of serotype A12 | Elicits virus neutralising antibodies in mice after transcutaneous immunisation | ELISA | Log10 antibody titres=3.8 after second booster | Abdominal skin of BALB/c mice | 15734548 |
| 1190 | CGSGVRGDFGSLAPR VARQL | Peptide 141–159 from the VP1 protein of serotype A12 | Elicits virus neutralising antibodies in mice after transcutaneous immunisation | ELISA | Log10 antibody titres=4.5 after third booster | Abdominal skin of BALB/c mice | 15734548 |
| 1191 | CGSGVRGDFGSLAPR VARQL | Peptide 141–159 from the VP1 protein of serotype A12 | Elicits virus neutralising antibodies in mice after transcutaneous immunisation | Neutralisation assay | Neutralisation indices of anti-peptide antibody responses=2.5 after first booster | Abdominal skin of BALB/c mice | 15734548 |
| 1192 | CGSGVRGDFGSLAPR VARQL | Peptide 141–159 from the VP1 protein of serotype A12 | Elicits virus neutralising antibodies in mice after transcutaneous immunisation | Neutralisation assay | Neutralisation indices of anti-peptide antibody responses=2.1 after second booster | Abdominal skin of BALB/c mice | 15734548 |
| 1193 | CGSGVRGDFGSLAPR VARQL | Peptide 141–159 from the VP1 protein of serotype A12 | Elicits virus neutralising antibodies in mice after transcutaneous immunisation | Neutralisation assay | Neutralisation indices of anti-peptide antibody responses=2.7 after third booster | Abdominal skin of BALB/c mice | 15734548 |
| 1392 | lsaydpvdypysnsfakc | Retro-inverso HA 91-108 | Antigenic properties with increased resistance to proteolytic activity and consequently longer persistence in vivo | ELISA | Retro-inverso peptide induced high levels of serum IgG and lung IgA antibodies | Nasal cavity of mouse | 12220890 |