Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID | Sequence | Name | Nature of peptide or cargo | Assay | Tissue permeability | Tissue Sample | PUBMED ID |
|---|---|---|---|---|---|---|---|
| 1001 | ACSSSPSKHCG | TD1 | TD1 enhances the transdermal delivery of macromolecules | Franz diffusion cells | Significant increase in permeability of the peptide can be seen by the addition of ATP.The amount of protein that permeated the skin was determined with ELISA | Male SD rats skin cells | 25269793 |
| 1002 | AAPV | AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=0.46 μg/cm2/h, Permeability coefficient=1.50×10−4Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1003 | AAPV | C6(D)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=2.29 μg/cm2/h, Permeability coefficient=7.6×10−4 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1004 | AAPV | C6(L)-Laa- AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=0.50 μg/cm2/h, Permeability coefficient=1.6×10−4 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1005 | AAPV | C8(D,L)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=10.08 μg/cm2/h, Permeability coefficient= 3.3×10−3 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1006 | AAPV | C8(D)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=7.42 μg/cm2/h, Permeability coefficient=1.90×10−2 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1007 | AAPV | C8(L)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=1.37 μg/cm2/h, Permeability coefficient=4.50×10−4 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1008 | AAPV | C10(D,L)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=8.92 μg/cm2/h, Permeability coefficient=2.9×10−3 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1009 | RRRRRRRRRRRLILV LLAI | 11R-No. 10 | Melanogenesis inhibitory peptide | Confocal microscope | When TMR-11R was topically applied for 24 h, the signals were only observed on the surface of the skin. In contrast, 12 h later, strong signals were detected showing that TMR-11R had arrived at the skin basal layer. Moreover, 24 and 48 hours later, the signals had spread out more and were stronger in both epidermis and dermis | Skin from the back of a brown guinea pig | 24602570 |
| 1010 | GKRR | R4 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 25.16 ± 2.31 , Q48 (mg) 1167.05 ± 50.10 Drug content in skin (mg/cm2) 146 ± 6.44 | Human epidermal skin | 24134794 |
| 1011 | GKRR | R4 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 43.74 ± 4.15 , Q48(mg) 2064.72 ± 100.05 Drug content in skin (mg/cm2) 180 ± 8.23 | Human epidermal skin | 24134794 |
| 1012 | GKRR | R4 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Human epidermal skin | 24134794 |
| 1013 | GKKKRRRR | R8 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Human epidermal skin | 24134794 |
| 1014 | GKKKRRRR | R8 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Human epidermal skin | 24134794 |
| 1015 | GKKKRRRR | R8 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 78.07 ± 7.52, Q48 (mg) 3666.44 ± 162.70 Drug content in skin (mg/cm2) 378± 15.11 | Human epidermal skin | 24134794 |
| 1016 | GKKKKKKKRRRRRRRR | R16 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 21.43 ± 1.32 , Q48 (mg) 856.29 ± 39.50 Drug content in skin (mg/cm2) 151 ± 4.64 | Human epidermal skin | 24134794 |
| 1017 | GKKKKKKKRRRRRRRR | R16 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 23.46 ± 2.04 , Q48 (mg) 1106.03 ± 53.80 Drug content in skin (mg/cm2) 155 ± 4.85 | Human epidermal skin | 24134794 |
| 1018 | GKKKKKKKRRRRRRRR | R16 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 27.16 ± 2.65, Q48 (mg) 1256.61 ± 55.70, Drug content in skin (mg/cm2) 156 ± 6.26 | Human epidermal skin | 24134794 |
| 1019 | KETWWETWWTEWSQP KKKRKV | Pep-1 | Cell penetrating peptide | In vivo imaging | Significant permeability of the peptide can be seen in in vivo images | Mouse skin cells | 23601371 |
| 1020 | ACSSSPSKHCG | TDN | TD-1 has been testified to enhanced insulin transdermal delivery through hair follicles | Confocal Laser Scanning Microscopy | Significant permeability of the peptide can be seen in confocal images | Male SD rats skin cells | 23391375 |
| 1021 | ACSSKKSKHCG | TD-34 | TD-1 has been testified to enhanced insulin transdermal delivery through hair follicles | Confocal Laser Scanning Microscopy | Significant permeability of the peptide can be seen in confocal images | Male SD rats skin cells | 23391375 |
| 1022 | ACSSSPSKHCG | TD1 | TD1 enhances the transdermal delivery of macromolecules | Franz diffusion cells, immunity fluorescence techniques | Significant permeability of the peptide can be seen. The amount of protein that permeated the skin was determined with immunity fluorescence techniques | Male SD rats skin cells | 23385091 |
| 1023 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | TP could not pass through the skin due to the charge repulsion effect between the negative charge of the TP and the negative charge of the skin | Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1024 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts0.10± 0.01 µg/cm2 and fluxes 0.60 ± 0.06 µg/cm2·h | Acceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1025 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts 0.31 ± 0.04 µg/cm2 and fluxes 1.86 ± 0.24 µg/cm2·h | Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1026 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts 1.02 ± 0.05 µg/cm2 and fluxes 6.13± 0.28 µg/cm2·h | Acceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1027 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts 4.29 ± 0.40 µg/cm2 and fluxes 25.73 ± 2.40 µg/cm2·h | Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1076 | RRRRRRRR | Polyarginine | Cell penetrating peptide | Franz cell system | The SC, epidermal and dermal retention of SP for SP-NLC-R11 was 10.92, 7.02 and 0.82 mg/g of skin, respectively and the SC, epidermal and dermal retention of KP for KP-NLC-R11 was 0.75, 0.44 and 0.17 mg/g of skin, respectively | Skin from the dorsal surface of hairless rat | 22617521 |
| 1077 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell, HPLC | Cumulative amounts 0.20 ± 0.05 mg/cm2 and fluxes 0.20 ± 0.05 mg/cm2·h | Viable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | 22564052 |
| 1078 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell, HPLC | Cumulative amounts 0.43 ± 0.04 mg/cm2 and fluxes 0.14 ± 0.01 mg/cm2·h | Viable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | 22564052 |
| 1079 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell, HPLC | Cumulative amounts 0.59 ± 0.12 mg/cm2 and fluxes 0.10 ± 0.02 mg/cm2·h | Viable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | 22564052 |
| 1080 | CSNLSTCVLGKLSQELH KLQTYPRTNTGSGTP | sCT | Cell penetrating peptide | Vertical Franz diffusion cell, HPLC | Cumulative amounts 0.67 ± 0.10 mg/cm2 and fluxes 0.67 ± 0.10 mg/cm2·h | Viable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | 22564052 |
| 1081 | CSNLSTCVLGKLSQELH KLQTYPRTNTGSGTP | sCT | Cell penetrating peptide | Vertical Franz diffusion cell, HPLC | Cumulative amounts 0.33 ± 0.09 mg/cm2 and fluxes 0.11 ± 0.03 mg/cm2·h | Viable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | 22564052 |
| 1082 | CSNLSTCVLGKLSQELH KLQTYPRTNTGSGTP | sCT | Cell penetrating peptide | Vertical Franz diffusion cell, HPLC | Cumulative amounts 0.26 ± 0.02 mg/cm2 and fluxes 0.04 ± 0.00 mg/cm2·h | Viable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | 22564052 |
| 1083 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | Franz diffusion cell system, HPLC with photodiode array detector | 2-fold higher | Porcine ear skin | 22306174 |
| 1084 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | Franz diffusion cell system, HPLC with photodiode array detector | 2.8 wt% of the initial amount | Porcine ear skin | 22306174 |
| 1085 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | The scotch tape method | 0.35 wt% of Na-DFC | SC skin | 22306174 |
| 1086 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | The scotch tape method | 0.72 wt% of Na-DFC | SC skin | 22306174 |
| 1087 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | The scotch tape method | 0.3 wt% of Na-DFC | E + D skin | 22306174 |
| 1088 | RQIKIWFQNRRMKWKK | Penetratin (PEN) | Penetrate through cell and nucleus membranes | The scotch tape method | 0.57 wt% of Na-DFC | E + D skin | 22306174 |
| 1089 | (GSGAGA)n | Silk fibroin peptide (3,000 Da) | Anti-inflammatory | Histochemical analysis | Significant permeability of the silk peptide can be seen in histochemical images | Ear of mice | 22189681 |
| 1090 | (GSGAGA)n | Silk fibroin peptide (3,000 Da) | Anti-inflammatory | RT-PCR, Western blotting | Significant decrease in translation of COX-2, IL-6 and IL-1β in presence of silk peptide +Tat-SOD can be seen in western blot images | HaCaT keratinocytes | 22189681 |
| 1091 | RKKRRQRRR | Tat | Tat-SOD is anti-inflammatory | Histochemical analysis | Significant permeability of the Tat-SOD peptide can be seen in histochemical images | Ear of mice | 22189681 |
| 1092 | RKKRRQRRR | Tat | For promoting the skin penetration of molecules | Franz diffusion cells, HPLC | Permeation parameters observed were 15.74 ± 1.31% | Dorsal skin of mice | 22072881 |
| 1093 | RKKRRQRRR | Tat | For promoting the skin penetration of molecules | Franz diffusion cells, HPLC | Permeation parameters observed were5.74 ± 1.32% | Dorsal skin of mice | 22072881 |
| 1094 | RKKRRQRRR | Tat | For promoting the skin penetration of molecules | In vivo therapeutic efficacy assay | Show significantly improvement in wound and dry skin | Postaxial back skin of the mice | 22072881 |
| 1095 | RKKRRQRRR | Tat | For promoting the skin penetration of molecules | In vivo therapeutic efficacy assay | Show significantly improvement in wound and dry skin but lesser than EL/T | Postaxial back skin of the mice | 22072881 |
| 1096 | ACSSSPSKHCG | TD-1 | Transdermal Delivery enhancer | Fluorescence microscopy, Transmission electron microscopy | Penetrates to the stratum corneum of rat footpad 15 min after topical application. | Footpad skin of rats | 22009459 |
| 1097 | ACSSSPSKHCG | TD-1 | Transdermal Delivery enhancer | Fluorescence microscopy, Transmission electron microscopy | Co-administered FAM-labeled siRNA gathered in the hair follicle 30 min after application | Back skin of rats | 22009459 |
| 1098 | ACSSSPSKHCG | TD-1 | Transdermal Delivery enhancer | Fluorescence microscopy, Transmission electron microscopy | FAM-labeled siRNA and TD-1 topically co-administered penetrated from the stratum corneum to subcutaneous tissue 15 min after application | Footpad skin of rats | 22009459 |