Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID | Sequence | Name | Nature of peptide or cargo | Assay | Tissue permeability | Tissue Sample | PUBMED ID |
|---|---|---|---|---|---|---|---|
| 1408 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=1; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1/Control=1.2; where, 0=No corneal pathology; 1=Comeal infiltrate without significant melti | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1409 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1/Control=2.2, where, 0=No corneal pathology; 1=Comeal infiltrate without significant melting; 2=Grade I melting (none to one-third of the corneal surface); 3=Grade II melting (one-third to two-thirds of the corneal surface) and/or mild bulging; 4=Grade III melting (tw | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1410 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=1/Control=1.2; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1/Control=3.1, where, 0=No corneal pathology; 1=Comeal infiltrate without signi | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1411 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1/Control=4, where, 0=No corneal pathology; 1=Comeal infiltrate without significant melting; 2=Grade I melting (none to one-third of the corneal surface); 3=Grade II melting (one-third to two-thirds of the corneal surface) and/or mild bulging; 4=Grade III melting (two- | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1412 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=1.1/Control=2.7; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1/Control=4, where, 0=No corneal pathology; 1=Comeal infiltrate without signi | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1413 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1/Control=4, where, 0=No corneal pathology; 1=Comeal infiltrate without significant melting; 2=Grade I melting (none to one-third of the corneal surface); 3=Grade II melting (one-third to two-thirds of the corneal surface) and/or mild bulging; 4=Grade III melting (two- | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1414 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=1.2/Control=4.8; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1/Control=4, where, 0=No corneal pathology; 1=Comeal infiltrate without signi | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1415 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1/Control=4.2, where, 0=No corneal pathology; 1=Comeal infiltrate without significant melting; 2=Grade I melting (none to one-third of the corneal surface); 3=Grade II melting (one-third to two-thirds of the corneal surface) and/or mild bulging; 4=Grade III melting (tw | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1416 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=2.2/Control=5.3; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1/Control=4.9, where, 0=No corneal pathology; 1=Comeal infiltrate without sig | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1417 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=2.7/Control=5.3; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=1.3/Control=4.9, where, 0=No corneal pathology; 1=Comeal infiltrate without s | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1418 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=2/Control=4.9, where, 0=No corneal pathology; 1=Comeal infiltrate without significant melting; 2=Grade I melting (none to one-third of the corneal surface); 3=Grade II melting (one-third to two-thirds of the corneal surface) and/or mild bulging; 4=Grade III melting (tw | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1419 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=2.8/Control=4.9, where, 0=No corneal pathology; 1=Comeal infiltrate without significant melting; 2=Grade I melting (none to one-third of the corneal surface); 3=Grade II melting (one-third to two-thirds of the corneal surface) and/or mild bulging; 4=Grade III melting ( | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1420 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=4.1/Control=5.6; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=3/Control=4.9, where, 0=No corneal pathology; 1=Comeal infiltrate without sig | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1421 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=4.7/Control=5.6; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=3.5/Control=5, where, 0=No corneal pathology; 1=Comeal infiltrate without sig | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1422 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=4.9/Control=5.8; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=4/Control=5, where, 0=No corneal pathology; 1=Comeal infiltrate without signi | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1423 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=4.8/Control=5.8; Average clinical score according to hours-post inoculation for topically applied bacterial inoculum(treatment till 24 hours post inoculation): Inhibitor=4/Control=5, where, 0=No corneal pathology; 1=Comeal infiltrate without signi | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |
| 1424 | FA | Thiol based metalloproteinase inhibitor | Potent inhibitor of corneal coliagenase, alkali-induced corneal ulceration and P. aeruginosa elastase | Peptidase activity checked via enzyme assay, Clinical evaluation and scoring, Statistical analysis | Average clinical score according to hours-post inoculation for topically and subconjunctivally applied bacterial inoculum(treatment till 26 hours post inoculation): Inhibitor=5.2/Control=5.8, where, 0=No corneal pathology; 1=Comeal infiltrate without significant melting; 2=Grade I melting (none to one-third of the corneal surface); 3=Grade II melting (one-third to two-thirds of the corneal surface) and/or mild bulging; | One eye of the New Zealand White rabbits weighing between 2 and 2.5 kg was used as test and the other as control | 2127341 |