==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

Detailed description page of THPdb

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1847 details
Primary information
ThPP IDTh1235
Therapeutic Peptide/Protein NameProtein S human
SequenceANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRS view full sequnce in fasta
Functional ClassificationIb
Molecular Weight69000
Chemical FormulaNA
Isoelectric Point5.0-5.5 (7
HydrophobicityNA
Melting Point (℃)NA
Half LifeNA
DescriptionProtein S (also known as S-Protein) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by the PROS1 gene.
Indication/DiseaseTo prevent coagulation and stimulating fibrinolysis
PharmacodynamicsNA
Mechanism of ActionCofactor for activated protein C
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of DistributionNA
ClearanceNA
CategoriesAnticoagulant plasma protein
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameProtein S human
CompanyNA
Brand DiscriptionProtein S is a single chain vitamin K-dependent protein which is thought to function in both the coagulation and complement cascades (1,2). Approximately 60% of protein S circulating in plasma is complexed to C4b binding protein (C4BP). It has been suggested that g-carboxyglutamic acid (gla) dependent binding of protein S to negatively charged phospholipids may function to concentrate C4BP at cell surfaces following injury.
Prescribed forIn the coagulation system, protein S functions as an anticoagulant cofactor protein
Chemical NameNA
FormulationPurified protein S is supplied in 50% (vol/vol) glycerol/H2O
Physcial Appearnce Solid
Route of AdministrationNA
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.haemtech.com/products/cofactors/protein-s , http://www.abcam.com/natural-human-protein-s-ab184880.html , http://www.enzymeresearch.com/product/human-protein-s/
PubMed ID836809
3-D StructureN.A.