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Details of SAPdb entry with Sequence VF
Primary information
SAPdb ID 1018,
PMID17172307
Peptide NameNH2-Val-Phe-COOH
Peptide sequenceVF
N-Terminal ModificationFree
C-Terminal ModificationFree
Non-Terminal ModificationNone
Length2
Peptide/ConjuagatePeptide
Conjugate partnerNone
TechniqueTransmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM)
SolventAqueous dispersion
MethodDipeptide samples were diluted in 1,1,1,3,3,3 hexafluoro-2-propanol to obtain stocks of 100 mg/ml and 200 mg/ml, which were further diluted in water
Conc2% (w/v)
Temperature5.8
TemperatureRoom temperature
Year2007
Self assemblyYes
Type of Self assemblyNanofibrils
Tertiary Structure
(Technique)		Not Predicted),
Linear
NA
NA
Nanofiber
NA
VF
N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C=O
Primary information
SAPdb ID 1633,
PMID23795243
Peptide NameVF
Peptide sequenceVF
N-Terminal ModificationFree
C-Terminal ModificationFree
Non-Terminal ModificationNone
Length2
Peptide/ConjuagatePeptide
Conjugate partnerNone
TechniqueInsilico method: MARTINI coarse - grained molecular dynamic
SolventWater
MethodA simulation for each dipeptide (in their zwitterionic form) was set up using the GROMACS molecular dynamics package. A cubic box with 300 dipeptides, placed randomly with a minimum distance of 3 Å between them, was solvated in standard MARTINI CG water (four water molecules per bead) to a final concentration of ∼0.4 M. A Berendsen thermostat and barostat36 were used to keep the temperature at 303 K and pressure at 1 bar, respectively. Bond lengths in aromatic side chains and the backbone side-chain bonds in I, V, and Y were constrained using the LINCS algorithm.37 All boxes were energy minimized using the steepest descent integrator and then equilibrated for 4 106 time steps of 25 fs. The total screening simulation time equates to 100 ns, but because of the smoothness of the CG potentials, this roughly equates to an effective 400 ns of atomistic simulation time
Conc0.4M
Temperature30 °C
Year2011
Self assemblyNo
Type of Self assemblyNone
Tertiary Structure
(Technique)		Not Predicted),
Linear
NA
NA
None
NA
VF
N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C=O
Primary information
SAPdb ID 1682,
PMID29890854
Peptide NameL-valine-Phenylalanine
Peptide sequenceVF
N-Terminal ModificationFree
C-Terminal ModificationFree
Non-Terminal ModificationNone
Length2
Peptide/Conjuagatepeptide
Conjugate partnerNone
Year2018
Self assemblyNo
Type of Self assemblyNA
Tertiary Structure
(Technique)		Not Predicted),
Linear
NA
NA
NA
NA
VF
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O
Primary information
SAPdb ID 1940,
PMID28589640
Peptide NameBoc-Val-Phe-OMe
Peptide sequenceVF
N-Terminal ModificationBoc (or t-butoxycarbonyl)
C-Terminal ModificationMethoxy
Non-Terminal ModificationNone
Length2
Peptide/ConjuagatePeptide
Conjugate partnerNone
TechniqueSEM, circular dichroism, attenuated total internal reflection-fourier transform infrared spectroscopy, X-ray diffraction and microscopy
SolventMethanol (MeOH), trifluoroethanol (TFE) and hexafluoroisopropanol (HFIP)
Conc6 mM
TemperatureRoom temperature
Incubation Time30 min
Year2017
Self assemblyYes
Type of Self assemblyNanotubes
Tertiary Structure
(Technique)		Not Predicted),
Linear
NA
NA
Nanotube
NA
VF
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O