Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0086Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAinduce type I interferons (IFN) and other cytokines production.NA106794112000NA
PRRID_0086Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAinduce type I interferons (IFN) and other cytokines production.NA106794112000NA
PRRID_0104Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantScavenger receptor class AScavenger receptor (SR)NANANANANANANANA18522092001NA
PRRID_0104Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantScavenger receptor class AScavenger receptor (SR)NANANANANANANANA18522092001NA
PRRID_0176Lipopolysaccharide (LPS)

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H. pylori (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)SyntheticIt strongly binds to the DC-SIGN.DC-SIGNC type Lectin (CTL/CLR)K562 cellsDendritic cellsLectin domainNANANAIt induces the pathogen-driven inflammatory responses.ELISA125743252003NA
PRRID_0176Lipopolysaccharide (LPS)

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H. pylori (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)SyntheticIt strongly binds to the DC-SIGN.DC-SIGNC type Lectin (CTL/CLR)K562 cellsDendritic cellsLectin domainNANANAIt induces the pathogen-driven inflammatory responses.ELISA125743252003NA
PRRID_0246Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNANAO60603.fastaO60603784NANA168612912006Pubchem Assay
PRRID_0246Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNANAO60603.fastaO60603784NANA168612912006Pubchem Assay
PRRID_0254Lipopolysaccharide (LPS)

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enterobacterial bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA173531992007Pubchem Assay
PRRID_0254Lipopolysaccharide (LPS)

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enterobacterial bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA173531992007Pubchem Assay
PRRID_0255Lipopolysaccharide (LPS)

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E.coli strain O111:B4(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA173531992007Pubchem Assay
PRRID_0255Lipopolysaccharide (LPS)

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E.coli strain O111:B4(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA173531992007Pubchem Assay
PRRID_0256Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)BALB/c and C57BL/6 miceSpleen cellsToll- IL-1R domainQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA174043012007Pubchem Assay
PRRID_0256Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)BALB/c and C57BL/6 miceSpleen cellsToll- IL-1R domainQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA174043012007Pubchem Assay
PRRID_0303Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS binds to vitellogenin with high affinity.VitellogeninPhospholipoglycoproteinHexagrammos otakiiMacropahesNANANANAVg is involved in anti-infectious response, functions as an opsonin that can enhance macrophage phagocytosis.ELISA183984662008NA
PRRID_0303Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS binds to vitellogenin with high affinity.VitellogeninPhospholipoglycoproteinHexagrammos otakiiMacropahesNANANANAVg is involved in anti-infectious response, functions as an opsonin that can enhance macrophage phagocytosis.ELISA183984662008NA
PRRID_0304Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBbFREP can specifically bind LPS.BbFREPMultivalent Pattern recognition receptor (PRR)Amphioxus (Branchiostoma belcheri)hepatic caecumfibrinogen-like (FBG) domainNANANAIt leads to the bacteriolytic activity via interaction with LPS.ELISA185332662008NA
PRRID_0304Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBbFREP can specifically bind LPS.BbFREPMultivalent Pattern recognition receptor (PRR)Amphioxus (Branchiostoma belcheri)hepatic caecumfibrinogen-like (FBG) domainNANANAIt leads to the bacteriolytic activity via interaction with LPS.ELISA185332662008NA
PRRID_0305Lipopolysaccharide (LPS)

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E. coli 055:B5(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHuman prostate epithelial PC3 cellsLRRO00206.fastaO00206839It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines.ELISA186498752008Pubchem Assay
PRRID_0305Lipopolysaccharide (LPS)

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E. coli 055:B5(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHuman prostate epithelial PC3 cellsLRRO00206.fastaO00206839It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines.ELISA186498752008Pubchem Assay
PRRID_0306Lipopolysaccharide (LPS)

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Escherichia coli 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalGalectin-3 directly interacts with LPS and blocks LPS-induced inflammatory response.Galectin-3Pattern recognition receptor (PRR)MiceBone Marrow Derived Macrophages.NAQ9JHE4 .fastaQ9JHE4423Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation, which protects the host from endotoxin shock.ELISA186849692008Pubchem Assay
PRRID_0306Lipopolysaccharide (LPS)

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Escherichia coli 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalGalectin-3 directly interacts with LPS and blocks LPS-induced inflammatory response.Galectin-3Pattern recognition receptor (PRR)MiceBone Marrow Derived Macrophages.NAQ9JHE4 .fastaQ9JHE4423Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation, which protects the host from endotoxin shock.ELISA186849692008Pubchem Assay
PRRID_0307Lipopolysaccharide (LPS)

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Burkholderia pseudomallei(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalStimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)HEK293 cellsLRRQ9QUK6.fastaQ9QUK6835It has a immunostimulatory roleELISA186914132008Pubchem Assay
PRRID_0307Lipopolysaccharide (LPS)

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Burkholderia pseudomallei(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalStimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)HEK293 cellsLRRQ9QUK6.fastaQ9QUK6835It has a immunostimulatory roleELISA186914132008Pubchem Assay
PRRID_0308Lipopolysaccharide (LPS)

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Burkholderia pseudomallei(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalStimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-α, MIP-2, and IL-10.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293 cellsLRRO00206.fastaO00206839It has a immunostimulatory roleELISA186914132008Pubchem Assay
PRRID_0308Lipopolysaccharide (LPS)

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Burkholderia pseudomallei(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalStimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-α, MIP-2, and IL-10.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293 cellsLRRO00206.fastaO00206839It has a immunostimulatory roleELISA186914132008Pubchem Assay
PRRID_0309Lipopolysaccharide (LPS)

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Escherichia coli (055:B5) (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt leads to the activation of the transcription factor nuclear factor kappa B (NFKB) in caput and cauda epididymides.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)RatEpididymisLRRNANANARat epididymis is fully capable of initiating an inflammatory response to lipopolysaccharide (LPS) from Escherichia coli through activation of Tolllike receptor 4.EMSA187034212008NA
PRRID_0309Lipopolysaccharide (LPS)

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Escherichia coli (055:B5) (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt leads to the activation of the transcription factor nuclear factor kappa B (NFKB) in caput and cauda epididymides.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)RatEpididymisLRRNANANARat epididymis is fully capable of initiating an inflammatory response to lipopolysaccharide (LPS) from Escherichia coli through activation of Tolllike receptor 4.EMSA187034212008NA
PRRID_0310Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS stimulation leads to the activation of phospholipase CToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophages and Dendritic cellsNAQ9QUK6.fastaQ9QUK6835It has the role in immuno inflammation.ELISA182339612008Pubchem Assay
PRRID_0310Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS stimulation leads to the activation of phospholipase CToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophages and Dendritic cellsNAQ9QUK6.fastaQ9QUK6835It has the role in immuno inflammation.ELISA182339612008Pubchem Assay
PRRID_0356Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantAgGNBPA1Gram-negative Bacteria-binding Protein (GNBPs)Anopheles gambiaesalivary gland and thoraxβ-1,3-glucan binding domainNANANANAin vitro bacterial binding assay182372832008NA
PRRID_0356Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantAgGNBPA1Gram-negative Bacteria-binding Protein (GNBPs)Anopheles gambiaesalivary gland and thoraxβ-1,3-glucan binding domainNANANANAin vitro bacterial binding assay182372832008NA
PRRID_0596intranigral Lipopolysaccharide (LPS) injection

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exogenous (others)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)PD animal modelmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death.NA207066422010Pubchem Assay
PRRID_0596intranigral Lipopolysaccharide (LPS) injection

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exogenous (others)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)PD animal modelmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death.NA207066422010Pubchem Assay
PRRID_0608Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalK63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagyToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Plasma MembraneLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It leads to autophagy and hence clearance of the pathogenNA207986082010Pubchem Assay
PRRID_0608Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalK63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagyToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Plasma MembraneLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It leads to autophagy and hence clearance of the pathogenNA207986082010Pubchem Assay
PRRID_0609Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalOn binding to the receptor it leads to the release of an array of cytokinesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)P815 cellsNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Immunostimulation and inflammationNA207985182010Pubchem Assay
PRRID_0609Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalOn binding to the receptor it leads to the release of an array of cytokinesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)P815 cellsNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Immunostimulation and inflammationNA207985182010Pubchem Assay
PRRID_0610Lipopolysaccharide (LPS)

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M. tuberculosis (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0610Lipopolysaccharide (LPS)

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M. tuberculosis (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0611Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0611Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0612Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalSecretion of proinflammatory cytokines such as TFG-β and IL-6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DF-MSCs & DP-MSCsToothLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207315362010Pubchem Assay
PRRID_0612Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalSecretion of proinflammatory cytokines such as TFG-β and IL-6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DF-MSCs & DP-MSCsToothLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207315362010Pubchem Assay
PRRID_0613Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)stage 3-4 CKD and HD patientsCD14+ MonocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207292662010Pubchem Assay
PRRID_0613Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)stage 3-4 CKD and HD patientsCD14+ MonocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207292662010Pubchem Assay
PRRID_0614Lipopolysaccharide (LPS)

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S. aureus (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)C57BL/6 MiceMacropahgesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0614Lipopolysaccharide (LPS)

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S. aureus (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)C57BL/6 MiceMacropahgesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0615Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLps is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0615Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLps is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0616Lipopolysaccharide (LPS)

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Escherichia coli O111: B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicemacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207284332010Pubchem Assay
PRRID_0616Lipopolysaccharide (LPS)

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Escherichia coli O111: B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicemacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207284332010Pubchem Assay
PRRID_0617Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalReduced HIV-1 expression and cell toxicity in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0617Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalReduced HIV-1 expression and cell toxicity in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0618Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0618Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0619Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR-4 Thre399Ile)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0619Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR-4 Thre399Ile)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0620Lipopolysaccharide (LPS)

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Bacterial strainsCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0620Lipopolysaccharide (LPS)

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Bacterial strainsCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0621Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a signaling cascade that utilizes both the MyD88- and TRIF-dependent pathways, leading to NF-kB and IRF3/7 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)dendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0621Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a signaling cascade that utilizes both the MyD88- and TRIF-dependent pathways, leading to NF-kB and IRF3/7 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)dendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0622Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)New Zealand White rabbitsNALeucine-rich Repeat (LRR) DomainNANANAInvolvement of exogenous TLR ligands during arteriogenesisNA207086242010NA
PRRID_0622Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)New Zealand White rabbitsNALeucine-rich Repeat (LRR) DomainNANANAInvolvement of exogenous TLR ligands during arteriogenesisNA207086242010NA
PRRID_0623Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver diseaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacropahgesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the inflammation of the cellsNA207066772010Pubchem Assay
PRRID_0623Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver diseaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacropahgesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the inflammation of the cellsNA207066772010Pubchem Assay
PRRID_0624Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835produce a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injuryNA207066422010Pubchem Assay
PRRID_0624Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835produce a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injuryNA207066422010Pubchem Assay
PRRID_0625Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces the expression of nociceptin, an opioid-related neuropeptideNA207066422010Pubchem Assay
PRRID_0625Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces the expression of nociceptin, an opioid-related neuropeptideNA207066422010Pubchem Assay
PRRID_0626Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMicrogliaLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injuryNA207066422010Pubchem Assay
PRRID_0626Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMicrogliaLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injuryNA207066422010Pubchem Assay
PRRID_0627Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)CNSNALeucine-rich Repeat (LRR) DomainNANANAIt cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampusNA207066422010NA
PRRID_0627Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)CNSNALeucine-rich Repeat (LRR) DomainNANANAIt cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampusNA207066422010NA
PRRID_0628Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)AD Mice's hippocampusmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Involved in the clearance of Aβ deposits in the brainNA207066422010Pubchem Assay
PRRID_0628Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)AD Mice's hippocampusmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Involved in the clearance of Aβ deposits in the brainNA207066422010Pubchem Assay
PRRID_0629Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduced the secretion of IL-6 and IL-9Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanperipheral mononuclear cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207031562010Pubchem Assay
PRRID_0629Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduced the secretion of IL-6 and IL-9Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanperipheral mononuclear cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207031562010Pubchem Assay
PRRID_0630Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAI-ankyrin-repeatsankyrin-repeatsMicesmall intestine, trachea, cornea, and conjunctiva, liver and kidney tissueNANANANAsuppress the production of proinflammatory cytokinesNA207031562010NA
PRRID_0630Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAI-ankyrin-repeatsankyrin-repeatsMicesmall intestine, trachea, cornea, and conjunctiva, liver and kidney tissueNANANANAsuppress the production of proinflammatory cytokinesNA207031562010NA
PRRID_0631Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAMAILankyrin-repeatsHumancorneal and conjunctival epitheliaNANANANAsuppress the production of proinflammatory cytokinesNA207031562010NA
PRRID_0631Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAMAILankyrin-repeatsHumancorneal and conjunctival epitheliaNANANANAsuppress the production of proinflammatory cytokinesNA207031562010NA
PRRID_0632Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)RatmyocardiumLeucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835NANA206975482010Pubchem Assay
PRRID_0632Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)RatmyocardiumLeucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835NANA206975482010Pubchem Assay
PRRID_0633Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAsCD14Pattern recognition receptor (PRR)RatmyocardiumNAQ63691.fastaQ63691372NANF-206975482010Pubchem Assay
PRRID_0633Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAsCD14Pattern recognition receptor (PRR)RatmyocardiumNAQ63691.fastaQ63691372NANF-206975482010Pubchem Assay
PRRID_0634Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Bombyx moriNANANANANAIt performs crucial functions in the response of anti-bacteria and fungiNA206595622010NA
PRRID_0634Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Bombyx moriNANANANANAIt performs crucial functions in the response of anti-bacteria and fungiNA206595622010NA
PRRID_0635Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (cfLGBP)Pattern recognition receptor (PRR)Chlamys farreriHemocytes, gills and mantleNANANANAIt is involved in pathogens recognition and bacterial agglutination.NA206595622010NA
PRRID_0635Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (cfLGBP)Pattern recognition receptor (PRR)Chlamys farreriHemocytes, gills and mantleNANANANAIt is involved in pathogens recognition and bacterial agglutination.NA206595622010NA
PRRID_0636Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalThe binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCord blood cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA206360302010Pubchem Assay
PRRID_0636Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalThe binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCord blood cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA206360302010Pubchem Assay
PRRID_0637Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contractionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanIntestinal FibroblastsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury.Luciferase assay206322822010Pubchem Assay
PRRID_0637Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contractionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanIntestinal FibroblastsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury.Luciferase assay206322822010Pubchem Assay
PRRID_0638Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0638Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0639Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B8 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)Wistar RatPineal gland (pinealocytes)NAQ63691.fastaQ63691372The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF and inhibiting melatonin synthesisNA205868882010Pubchem Assay
PRRID_0639Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B8 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)Wistar RatPineal gland (pinealocytes)NAQ63691.fastaQ63691372The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF and inhibiting melatonin synthesisNA205868882010Pubchem Assay
PRRID_0640Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B9 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Wistar RatPineal gland (pinealocytes)Leucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory responseEMSA205868882010Pubchem Assay
PRRID_0640Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B9 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Wistar RatPineal gland (pinealocytes)Leucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory responseEMSA205868882010Pubchem Assay