|
|
|
|
Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us |
|
| PolysacDB ID | 2265 |
| Carbohydrate Name | Y O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Shigella flexneri (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Heat-killed S. flexnerf bacteria serotype Y |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab MASF Y-1 |
| Antibody Type Class | N/A |
| Assay System | ELISA, FARR assay |
| Cross Reactivity | This Mab bound only to LPS of serotypes 4a and Y. In the glycoconjugate ELISA, MASF Y-1 bound only to the octasaccharide-(cdabcdab') and the decasaccharide-(abcdabcdab') BSA conjugate |
| Proposed Epitope | This Mab bound to intrachain determinants |
| IEDB Epitope | 76764 |
| Proposed Utility | This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide |
| Curator ID | AA + AS |
| Date of Curation | 15-03-2011 |
| References | 2438343 |
| PolysacDB ID | 2266 |
| Carbohydrate Name | Y O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Shigella flexneri (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Heat-killed S. flexnerf bacteria serotype Y |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab MASF Y-2 |
| Antibody Type Class | N/A |
| Assay System | ELISA, FARR assay |
| Cross Reactivity | MASF Y-2 bound exclusively to LPS of serotype Y. In the glycoconjugate ELISA. these antibodies bound only to the octa- and decasaccharide-BSA antigens |
| Proposed Epitope | This Mab bound to intrachain determinants |
| IEDB Epitope | 76764 |
| Proposed Utility | This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide |
| Curator ID | AA + AS |
| Date of Curation | 15-03-2011 |
| References | 2438343 |
| PolysacDB ID | 2267 |
| Carbohydrate Name | Y O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Shigella flexneri (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Heat-killed S. flexnerf bacteria serotype Y |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab MASF Y-3 |
| Antibody Type Class | N/A |
| Assay System | ELISA, FARR assay |
| Cross Reactivity | MASF Y-3 bound to LPS of serotypes 2a. 3b. 4b. And Y |
| Proposed Epitope | The terminal nonreducing end of the O-polysaccharide complementary to the tetrasaccharide repeating unit |
| IEDB Epitope | 76696 |
| Proposed Utility | This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide |
| Curator ID | AA + AS |
| Date of Curation | 15-03-2011 |
| References | 2438343 |
| PolysacDB ID | 2268 |
| Carbohydrate Name | Y O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Shigella flexneri (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Heat-killed S. flexnerf bacteria serotype Y |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab MASF Y-4 |
| Antibody Type Class | N/A |
| Assay System | ELISA, FARR assay |
| Cross Reactivity | MASF Y-4 bound to LPS of serotypes 2a. 3b, 4a, 4b, 5a, and Y |
| Proposed Epitope | The terminal nonreducing end of the O-polysaccharide complementary to the tetrasaccharide repeating unit |
| IEDB Epitope | 76696 |
| Proposed Utility | This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide |
| Curator ID | AA + AS |
| Date of Curation | 15-03-2011 |
| References | 2438343 |
| PolysacDB ID | 2269 |
| Carbohydrate Name | Y O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Shigella flexneri (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Heat-killed S. flexnerf bacteria serotype Y |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab MASF Y-5 |
| Antibody Type Class | N/A |
| Assay System | ELISA, FARR assay |
| Cross Reactivity | The rat Mab (MASF Y-5) bound LPS of serotypes 2a, 3b, 4a, and Y, all carrying the group antigen 3,4. It bound to the tetrasaccharides-( abcd), (bcda), [cdab'), (dabc), the octasaccharide-(cdabcdab'), and the decasaccharide-BSA (abcdabcdab ') glycoconjugates |
| Proposed Epitope | This Mab bound to intrachain determinants |
| IEDB Epitope | 76764 |
| Proposed Utility | This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide |
| Curator ID | AA + AS |
| Date of Curation | 15-03-2011 |
| References | 2438343 |
| PolysacDB ID | 2270 |
| Carbohydrate Name | Y O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Shigella flexneri (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Heat-killed S. flexnerf bacteria serotype Y |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Antisera |
| Antibody Type Class | N/A |
| Assay System | ELISA, FARR assay |
| Cross Reactivity | The polyclonal rabbit anti-group antigen 3.4 antibodies reacted with the lb, 2a, 3b, 4a. 4b, and Y LPS. They did not bind to1a and 5a. In glycoconjugate ELISA's it bound to all saccharides especially abcd- and decasaccharide- BSA antigens |
| Proposed Epitope | Antigen 3,4 seemed to be the epitope |
| IEDB Epitope | 76696 |
| Proposed Utility | This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide |
| Curator ID | AA + AS |
| Date of Curation | 16-03-2011 |
| References | 2438343 |
|
Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |