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| PolysacDB ID | 2490 |
| Carbohydrate Name | Ssp-4 (amastigote surface glycoprotein) (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe Name | Trypanosoma cruzi amastigotes (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Ssp-4 is an amastigote-specific 84 KDa surface component defined by monoclonal antibody (MAb) 2C2, that was shown to be linked to the membrane by a GPI anchor. The epitope defined by MAb 2C2 is homogeneously distributed over the amastigote surface throughout the intracellular life cycle until it is gradually shed through a phospholipase-dependent mechanism during transformation into trypomastigote |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Mixtures of heat-inactivated intracellular and extracellular amastigotes |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 1D9 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA, immunoblotting, immuno-electron microscopy and confocal immunofluorescence |
| Cross Reactivity | This Mab cross-reacts with membrane of amastigotes from 569, 588, 573, 587 and SC2005 isolates, similar to the G isolate. It also reacts with the CL isolate |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab reacted with cytoplasmic membrane-bound compartments of the amastigotes. This Mab specifically inhibited cell invasion by G and 588, but not CL strains |
| Curator ID | AA + AS |
| Date of Curation | 02-06-2011 |
| References | 9225447 |
| PolysacDB ID | 2491 |
| Carbohydrate Name | Ssp-4 (amastigote surface glycoprotein) (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe Name | Trypanosoma cruzi amastigotes (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Ssp-4 is an amastigote-specific 84 KDa surface component defined by monoclonal antibody (MAb) 2C2, that was shown to be linked to the membrane by a GPI anchor. The epitope defined by MAb 2C2 is homogeneously distributed over the amastigote surface throughout the intracellular life cycle until it is gradually shed through a phospholipase-dependent mechanism during transformation into trypomastigote |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Mixtures of heat-inactivated intracellular and extracellular amastigotes |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 3G8 |
| Antibody Type Class | N/A |
| Assay System | ELISA, immunoblotting, immuno-electron microscopy and confocal immunofluorescence |
| Cross Reactivity | N/A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab reacted with cytoplasmic membrane-bound compartments of the amastigotes. This Mab specifically inhibited cell invasion by G and 588, but not CL strains |
| Curator ID | AA + AS |
| Date of Curation | 03-06-2011 |
| References | 9225447 |
| PolysacDB ID | 2492 |
| Carbohydrate Name | Ssp-4 (amastigote surface glycoprotein) (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe Name | Trypanosoma cruzi amastigotes (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Ssp-4 is an amastigote-specific 84 KDa surface component defined by monoclonal antibody (MAb) 2C2, that was shown to be linked to the membrane by a GPI anchor. The epitope defined by MAb 2C2 is homogeneously distributed over the amastigote surface throughout the intracellular life cycle until it is gradually shed through a phospholipase-dependent mechanism during transformation into trypomastigote |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Psoralen/UV-inactivated intracellular amastigotes |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 2B7 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA, immunoblotting, immuno-electron microscopy and confocal immunofluorescence |
| Cross Reactivity | N/A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab reacted with cytoplasmic membrane-bound compartments of the amastigotes |
| Curator ID | AA + AS |
| Date of Curation | 03-06-2011 |
| References | 9225447 |
| PolysacDB ID | 2493 |
| Carbohydrate Name | Ssp-4 (amastigote surface glycoprotein) (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe Name | Trypanosoma cruzi amastigotes (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Ssp-4 is an amastigote-specific 84 KDa surface component defined by monoclonal antibody (MAb) 2C2, that was shown to be linked to the membrane by a GPI anchor. The epitope defined by MAb 2C2 is homogeneously distributed over the amastigote surface throughout the intracellular life cycle until it is gradually shed through a phospholipase-dependent mechanism during transformation into trypomastigote |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Mixtures of heat-inactivated intracellular and extracellular amastigotes |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 3B9 |
| Antibody Type Class | N/A |
| Assay System | ELISA, immunoblotting, immuno-electron microscopy and confocal immunofluorescence |
| Cross Reactivity | N/A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab reacted with cytoplasmic membrane-bound compartments of the amastigotes |
| Curator ID | AA + AS |
| Date of Curation | 03-06-2011 |
| References | 9225447 |
| PolysacDB ID | 2494 |
| Carbohydrate Name | Ssp-4 (amastigote surface glycoprotein) (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe Name | Trypanosoma cruzi amastigotes (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Ssp-4 is an amastigote-specific 84 KDa surface component defined by monoclonal antibody (MAb) 2C2, that was shown to be linked to the membrane by a GPI anchor. The epitope defined by MAb 2C2 is homogeneously distributed over the amastigote surface throughout the intracellular life cycle until it is gradually shed through a phospholipase-dependent mechanism during transformation into trypomastigote |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Mixtures of heat-inactivated intracellular and extracellular amastigotes |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 4B9 |
| Antibody Type Class | N/A |
| Assay System | ELISA, immunoblotting, immuno-electron microscopy and confocal immunofluorescence |
| Cross Reactivity | N/A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab reacted with cytoplasmic membrane-bound compartments of the amastigotes |
| Curator ID | AA + AS |
| Date of Curation | 04-06-2011 |
| References | 9225447 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |