| PolysacDB ID | 2412 |
| Carbohydrate Name | Phosphorylcholine (PC) (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Streptococcus pneumoniae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A
|
| BCSDB Structure | N/A |
| Proposed Function | Antibodies directed against phosphorylcholine (PC), a major epitope on the cell wall polysaccharide, protect against pneumococcal infections in mice; the role of anti-PC antibodies in humans, however, remains controversial |
| Antigenic Nature | ASRNKANDYTTEYSASVKGRFIVS [peptide1] |
| Carrier Name | Bovine serum albumin |
| Conjugate Method | BSA (5 mg) was dissolved in a 0.1 M sodium citrate solution (pH 5.5; 500 ml) to provide a BSA:peptide ratio of 1:25. Glutaraldehyde (0.1%) was added, and the solution was incubated for 1 h at room temperature. The reaction mixture was dialyzed against phosphate-buffered saline (PBS) for 5 days at 4°C |
| Antibodies | Antisera |
| Antibody Type Class | N/A |
| Assay System | ELISA, Opsonization and protection assays |
| Cross Reactivity | N/A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This peptide was able to inhibit the binding of anti-PC monoclonal antibodies to PC-BSA |
| Curator ID | AA + AS |
| Date of Curation | 03-05-2011
|
| References | 10992485 |