PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID1041
Carbohydrate NamePhosphocholine   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NamePneumococcal strain WU(12)   (NCBI Taxonomy)   (Drugpedia)
Basic StructurePhosphocholine (PC) is an intermediate in the synthesis of phosphatidylcholine in tissues. Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP + Choline into Phosphocholine and ADP
BCSDB StructureN/A
Proposed FunctionPhosphocholine is determinant of lipotechoic acids of Gram positive bacteria
Antigenic NatureCell extract and heat killed Pneumococcal strain EF3296.
Carrier NameNil
Conjugate MethodNil
AntibodiesSR4W1
Antibody Type ClassIgG2a
Assay SystemBlood bactericidal assay, hemolytic activity
Cross ReactivityN/A
Proposed EpitopePhosphocholine
IEDB EpitopeN/A
Proposed UtilityMonoclonal antibody SR4W1 can protect mice against Pneumococcal infections.
Curator IDAA + AS
Date of Curation12-01-2010
ReferencesPMC313299

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