PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID1743
Carbohydrate NamePhenolic glycolipid TB antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium tuberculosis canetti   (NCBI Taxonomy)   (Drugpedia)
Basic StructurePhenolic glycolipid consist of phenol phthiocerol as a common structure and a carbohydrate determinant that consists of 2,3,4-Me3Fuc-Rha-2-O-MeRha residues
BCSDB StructureN/A
Proposed FunctionIt has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab III604
Antibody Type ClassIgG3
Assay SystemELISA and dot ELISA
Cross ReactivityThis Mab was specific to M. tuberculosis phenolic glycolipid and did not cross-react with other phenolic glycolipids from Mycobacterium leprae, M. bovis, and M. kansasii
Proposed EpitopeN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may be useful as a diagnostic reagent
Curator IDAA + AS
Date of Curation20-10-2010
ReferencesPMC270589

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