PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID1761
Carbohydrate NamePeptide mimotope   (Drugpedia)
Carbohydrate ClassGlycoprotein
Microbe NameMycobacterium tuberculosis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe peptide consisted of the following sequence : QEPLMGTVPIRAGGGS
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NaturePurified peptide
Carrier NameNil
Conjugate MethodNil
AntibodiesPolysera
Antibody Type ClassN/A
Assay SystemELISA, immunoblotting
Cross ReactivityThis antisera recognized mannosylated Mycobacterium tuberculosis cell-wall antigens arabinomannan, lipoarabinomannan and the glycosylated recombinant protein Apa. The antisera also cross-reacted with mannans from Saccharomyces cerevisiae, but did not react with phosphatidyl-inositol-di-mannoside or arabinogalactan from Mycobacteria
Proposed EpitopeThe epitope was proposed to be oligomannosidic in nature
IEDB EpitopeN/A
Proposed UtilityThis peptide mimotope can used as surrogate reagent for immunodiagnosis of tuberculosis
Curator IDAA + AS
Date of Curation24-10-2010
ReferencesPMC1134969

Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020