PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID1511
Carbohydrate NameLipopolysaccharide and capsular polysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameActinobacillus pleuropneumoniae serotype b strains 81-750 and B78-3760   (NCBI Taxonomy)   (Drugpedia)
Basic StructureO-polysaccharide structure of strain 81-750 is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues.
BCSDB StructureN/A
Proposed FunctionLPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus
Antigenic NatureFormaldehyde killed cells of strains 81-750 and B78-3760 and LPS coated whole cells of strain 81-750.
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 3A5
Antibody Type ClassIgG1
Assay SystemELISA and dot ELISA
Cross ReactivityThis antibody cross-reacted strongly with CPS of serotype 5b
Proposed EpitopeN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab can be used to detect the presence of bacterial antigens in lungs from infected animals
Curator IDAA + AS
Date of Curation08-08-2010
ReferencesPMC1263782

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