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| PolysacDB ID | 1171 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Bordetella pertusis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B |
| BCSDB Structure | N/A |
| Proposed Function | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature | N/A |
| Carrier Name | N/A |
| Conjugate Method | N/A |
| Antibodies | Mab G10F8C3 |
| Antibody Type Class | IgG3 |
| Assay System | Immunoblotting, Protein A sepharose affinity chromatography, bactericidal assays |
| Cross Reactivity | This antibody was specific to B. pertusis strains |
| Proposed Epitope | This Mab reacts with the core oligosaccharide moeity |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab exhibits complement dependent bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition it was effective in reducing colonization by B. pertussis in both the lungs and tracheas of mice after aerosol infection |
| Curator ID | AA + AS |
| Date of Curation | 25-02-2010 |
| References | PMC258314 |
| PolysacDB ID | 1172 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Bordetella pertusis 9340 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B |
| BCSDB Structure | N/A |
| Proposed Function | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature | N-Lauroyl sarcosine membrane extract (SME) from B. pertussis 9340 |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab BL-1 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA,immunoblotting, Antibody accessibility radioimmunoassay, bactericidal asaay, competitive ELISA |
| Cross Reactivity | This antibody reacted with all B.pertusis strains, did not react with B. parapertusis or other gram negative bacteria but cross-reacted with 4 B. bronchiseptica strains which had LOS AB phenotype |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab was capable of inducing bactericidal activity in uitro. |
| Curator ID | AA + AS |
| Date of Curation | 25-02-2010 |
| References | 1713258 |
| PolysacDB ID | 1173 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Bordetella pertusis 9340 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B |
| BCSDB Structure | N/A |
| Proposed Function | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature | N-Lauroyl sarcosine membrane extract (SME) from B. pertussis 9340 |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab BL-3 |
| Antibody Type Class | IgM |
| Assay System | ELISA,immunoblotting, Antibody accessibility radioimmunoassay, bactericidal asaay, competitive ELISA |
| Cross Reactivity | This antibody reacted with all B.pertusis strains, did not react with B. parapertusis or other gram negative bacteria but cross-reacted with 4 B. bronchiseptica strains which had LOS AB phenotype |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab was capable of inducing bactericidal activity in uitro. |
| Curator ID | AA + AS |
| Date of Curation | 25-02-2010 |
| References | 1713258 |
| PolysacDB ID | 1174 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Bordetella pertusis 9340 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B |
| BCSDB Structure | N/A |
| Proposed Function | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature | N-Lauroyl sarcosine membrane extract (SME) from B. pertussis 9340 |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab BL-4 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA,immunoblotting, Antibody accessibility radioimmunoassay, bactericidal asaay, competitive ELISA |
| Cross Reactivity | This antibody reacted with all B.pertusis strains, did not react with B. parapertusis or other gram negative bacteria but cross-reacted with 4 B. bronchiseptica strains which had LOS AB phenotype |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab was capable of inducing bactericidal activity in uitro. |
| Curator ID | AA + AS |
| Date of Curation | 25-02-2010 |
| References | 1713258 |
| PolysacDB ID | 1175 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Bordetella pertusis 9340 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B |
| BCSDB Structure | N/A |
| Proposed Function | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature | N-Lauroyl sarcosine membrane extract (SME) from B. pertussis 9340 |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab BL-5 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA,immunoblotting, Antibody accessibility radioimmunoassay, bactericidal asaay, competitive ELISA |
| Cross Reactivity | This antibody reacted with all B.pertusis strains, did not react with B. parapertusis or other gram negative bacteria but cross-reacted with 4 B. bronchiseptica strains which had LOS AB phenotype |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab was capable of inducing bactericidal activity in uitro. |
| Curator ID | AA + AS |
| Date of Curation | 26-02-2010 |
| References | 1713258 |
| PolysacDB ID | 1176 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Bordetella pertusis 9340 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B |
| BCSDB Structure | N/A |
| Proposed Function | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature | N-Lauroyl sarcosine membrane extract (SME) from B. pertussis 9340 |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab BL-6 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA,immunoblotting, Antibody accessibility radioimmunoassay, bactericidal asaay, competitive ELISA |
| Cross Reactivity | This antibody reacted with all B.pertusis strains, did not react with B. parapertusis or other gram negative bacteria but cross-reacted with 4 B. bronchiseptica strains which had LOS AB phenotype |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | N/A |
| Curator ID | AA + AS |
| Date of Curation | 26-02-2010 |
| References | 1713258 |
| PolysacDB ID | 1177 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Bordetella pertusis 9340 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B |
| BCSDB Structure | N/A |
| Proposed Function | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature | N-Lauroyl sarcosine membrane extract (SME) from B. pertussis 9340 |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab BL-7 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA,immunoblotting, Antibody accessibility radioimmunoassay, bactericidal asaay, competitive ELISA |
| Cross Reactivity | This Mab reacted with all B.pertusis strains, did not react with B. parapertusis or other gram negative bacteria but cross-reacted with 4 B. bronchiseptica strains which had LOS AB phenotype |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | N/A |
| Curator ID | AA + AS |
| Date of Curation | 27-02-2010 |
| References | 1713258 |
| PolysacDB ID | 1180 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Bordetella pertusis 114 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed Function | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature | Partially purified preparations of fimbriae from B. pertussis 114 |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab G1OF8C3 |
| Antibody Type Class | IgG3 |
| Assay System | Immunoblotting |
| Cross Reactivity | Four strains of Bordetella bronchiseptica and three strains of Bordetella parapertussis were not agglutinated, nor were other gram-negative bacteria, such as Escherichia coli, N.meningitidis, Neisseria gonorrhoeae, Salmonella typhimurium, and Haemophilus influenzae |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab specifically agglutinated the bacteria. It could be useful in establishing a better-defined serotyping system for B. pertussis in which LOS A might be considered a typing antigen. This Mab can also be useful for the estimation of contaminating levels of endotoxin in vaccine preparations and for further studies on the structure of B. pertussis LOS. |
| Curator ID | AA + AS |
| Date of Curation | 27-02-2010 |
| References | PMC259348 |
| PolysacDB ID | 1181 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe Name | Bordetella pertusis 325 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed Function | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature | Partially purified preparations of fimbriae from B. pertussis 325 |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab E8D8B1 |
| Antibody Type Class | IgG3 |
| Assay System | Immunoblotting |
| Cross Reactivity | Four strains of Bordetella bronchiseptica and three strains of Bordetella parapertussis were not agglutinated, nor were other gram-negative bacteria, such as Escherichia coli, N.meningitidis, Neisseria gonorrhoeae, Salmonella typhimurium, and Haemophilus influenzae |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab specifically agglutinated the bacteria. It could be useful in establishing a better-defined serotyping system for B. pertussis in which LOS A might be considered a typing antigen. This Mab can also be useful for the estimation of contaminating levels of endotoxin in vaccine preparations and for further studies on the structure of B. pertussis LOS. |
| Curator ID | AA + AS |
| Date of Curation | 27-02-2010 |
| References | PMC259348 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |