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| PolysacDB ID | 1631 |
| Carbohydrate Name | Lipoarabinomannan-B (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | N/A |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Soluble extract of M. leprae |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab SAl.C7F |
| Antibody Type Class | IgG1 |
| Assay System | Antigen capture ELISA, direct binding assay, |
| Cross Reactivity | This Mab was specific to M. leprae and did not cross-react with lipoarabinomannan from M. tuberculosis |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab becomes applicable for monitoring several individual M . Leprae antigens such as lipoarabinomannan |
| Curator ID | AA + AS |
| Date of Curation | 25-09-2010 |
| References | 2467001 |
| PolysacDB ID | 1632 |
| Carbohydrate Name | Lipoarabinomannan-B (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | N/A |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Soluble extract of M. leprae |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab SAl.C11H |
| Antibody Type Class | IgG1 |
| Assay System | Antigen capture ELISA, direct binding assay, |
| Cross Reactivity | This Mab was specific to M. leprae even though it cross-reacted to a little extent with lipoarabinomannan from M. tuberculosis |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab becomes applicable for monitoring several individual M . Leprae antigens such as lipoarabinomannan |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | 2467001 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |