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| PolysacDB ID | 1007 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Heat killed Mycobacterium tuberculosis |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 5c11 |
| Antibody Type Class | IgM |
| Assay System | Indirect immunofluorescence, ELISA, western blotting |
| Cross Reactivity | This antibody cross-reacted with large number of mycobacterial species. |
| Proposed Epitope | Arabinose moiety of Lipoarabinomannan |
| IEDB Epitope | N/A |
| Proposed Utility | This antibody has been used in the detection of mycobacteria in clinical samples |
| Curator ID | AA + AS |
| Date of Curation | 02-01-2010 |
| References | PMC229406 |
| PolysacDB ID | 1010 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed Function | Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade |
| Antigenic Nature | Heat killed Mycobacterium tuberculosis |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | SMITB14 |
| Antibody Type Class | IgG1 |
| Assay System | N\A |
| Cross Reactivity | SMITB14 bound to whole M. tuberculosis bacteria (H37Rv and Harlingen strains) as well as to the attenuated BCG, but not to other species such as Escherichia coli strains of various O serotypes, Streptococcus pneumoniae isolates, strains of Salmonella, Yersinia enterocolitica and Y. pseudotuberculosis and Nocardia sp. |
| Proposed Epitope | Arabinomannan portion of the antigen |
| IEDB Epitope | N/A |
| Proposed Utility | This antibody might be involved in blocking of mycobacterial invasion. SMITB14 may prevent the uptake of M. tuberculosis through receptor(s) that facilitate bacterial survival and growth. |
| Curator ID | AA + AS |
| Date of Curation | 03-01-2010 |
| References | PMC1809178 |
| PolysacDB ID | 1011 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed Function | Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade |
| Antigenic Nature | Heat killed Mycobacterium tuberculosis |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab lam701 |
| Antibody Type Class | IgG3 |
| Assay System | Sandwich ELISA |
| Cross Reactivity | This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium |
| Proposed Epitope | N\A |
| IEDB Epitope | N/A |
| Proposed Utility | These antibodies could be used to detect mycobacterial antigens in sputum |
| Curator ID | AA + AS |
| Date of Curation | 03-01-2010 |
| References | 2127645 |
| PolysacDB ID | 1032 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole killed mycobacteria leprae cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab lam038 |
| Antibody Type Class | IgM |
| Assay System | Sandwich ELISA |
| Cross Reactivity | This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium |
| Proposed Epitope | N\A |
| IEDB Epitope | N/A |
| Proposed Utility | These antibodies could be used to detect mycobacterial antigens in sputum |
| Curator ID | AA + AS |
| Date of Curation | 09-01-2010 |
| References | 2127645 |
| PolysacDB ID | 1033 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole killed mycobacteria leprae cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab lam204 |
| Antibody Type Class | IgM |
| Assay System | Sandwich ELISA |
| Cross Reactivity | This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium |
| Proposed Epitope | N\A |
| IEDB Epitope | N/A |
| Proposed Utility | These antibodies could be used to detect mycobacterial antigens in sputum |
| Curator ID | AA + AS |
| Date of Curation | 09-01-2010 |
| References | 2127645 |
| PolysacDB ID | 1035 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole killed mycobacteria leprae cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab lam603 |
| Antibody Type Class | IgM |
| Assay System | Sandwich ELISA |
| Cross Reactivity | This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium |
| Proposed Epitope | N\A |
| IEDB Epitope | N/A |
| Proposed Utility | These antibodies could be used to detect mycobacterial antigens in sputum |
| Curator ID | AA + AS |
| Date of Curation | 09-01-2010 |
| References | 2127645 |
| PolysacDB ID | 1036 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole killed mycobacteria leprae cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab Cs-35 |
| Antibody Type Class | IgM |
| Assay System | Indirect and Competitive ELISA |
| Cross Reactivity | This antibody cross-reacted to M. tuberculosis and other Mycobacterium speices. |
| Proposed Epitope | β-D-Araf- (1-->2)-α-D-Araf-(1-->5)-α- D-Araf-(1-->5)-α-D-Araf within the branched hexa-Araf motif of mycobacterial arabinans |
| IEDB Epitope | 76797 |
| Proposed Utility | These antibodies could be used for screening of cell-wall mutants of mycobacteria lacking AG and AraLAM motifs and the recognition of biosynthetic intermediates of cell-wall polysaccharides unique to mycobacteria. |
| Curator ID | AA + AS |
| Date of Curation | 10-01-2010 |
| References | 12368438 |
| PolysacDB ID | 1644 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 901 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA |
| Cross Reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 27-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1645 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 903 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA |
| Cross Reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 27-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1646 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 904 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA |
| Cross Reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 27-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1647 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 906 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA |
| Cross Reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1648 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 922 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA |
| Cross Reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1649 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 908 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA |
| Cross Reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1650 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 920 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA |
| Cross Reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1651 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab A6C |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1652 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab A10G |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1653 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab A11C |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1654 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab A12B |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 30-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1655 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab A12C |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 30-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1656 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab A12D |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 30-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1657 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab B10E |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1658 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab C94 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1659 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab D1F |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1660 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab D11E |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1661 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed Function | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab D11G |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross Reactivity | This Mab was specific for M. leprae LAM |
| Proposed Epitope | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |