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| PolysacDB ID | 2486 |
| Carbohydrate Name | Glycoprotein GP72 (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe Name | Trypanosoma cruzi Z2 Esmeraldo/3 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | GP72 is a 72-kilodalton cell surface glycoprotein found on epimastigotes and metacyclic trypomastigotes |
| BCSDB Structure | N/A |
| Proposed Function | GP72 may regulate T. cruzi morphogenesis in the insect vector |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 8G2 B9 |
| Antibody Type Class | IgG2a |
| Assay System | ELISA, immunoblotiing, indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with T. cruzi BOL Z2, and Z3 but did not react with Z1 |
| Proposed Epitope | This Mab binds to phosphorylated sugar side chains, which comprise 85% of GP72 carbohydrate and contain ribose, xylose, and fucose |
| IEDB Epitope | N/A |
| Proposed Utility | Anti-T. cruzi monoclonal antibodies are considered to have important applications to epidemiological studies and the improved diagnosis and prognosis of Chagas' disease |
| Curator ID | AA + AS |
| Date of Curation | 01-06-2011 |
| References | 6380014 |
| PolysacDB ID | 2487 |
| Carbohydrate Name | Glycoprotein GP72 (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe Name | Trypanosoma cruzi Z2 Esmeraldo/3 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | GP72 is a 72-kilodalton cell surface glycoprotein found on epimastigotes and metacyclic trypomastigotes |
| BCSDB Structure | N/A |
| Proposed Function | GP72 may regulate T. cruzi morphogenesis in the insect vector |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab WIC 29.26 |
| Antibody Type Class | IgG2a |
| Assay System | ELISA, immunoblotiing, indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with T. cruzi BOL Z2, and Z3 but did not react with Z1. WIC 29.26 bound to only 2 of the 4 Trypanozome cruzi strains and 23 of the 50 clones tested |
| Proposed Epitope | WIC 29.26 binds to phosphorylated sugar side chains, which comprise 85% of GP72 carbohydrate and contain ribose, xylose, and fucose |
| IEDB Epitope | N/A |
| Proposed Utility | Anti-T. cruzi monoclonal antibodies are considered to have important applications to epidemiological studies and the improved diagnosis and prognosis of Chagas' disease |
| Curator ID | AA + AS |
| Date of Curation | 01-06-2011 |
| References | 6380014 |
| PolysacDB ID | 2488 |
| Carbohydrate Name | Glycoprotein GP72 (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe Name | Trypanosoma cruzi Z2 Esmeraldo/3 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | GP72 is a 72-kilodalton cell surface glycoprotein found on epimastigotes and metacyclic trypomastigotes |
| BCSDB Structure | N/A |
| Proposed Function | GP72 may regulate T. cruzi morphogenesis in the insect vector |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 7C6 D7 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, immunoblotiing, indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with T. cruzi BOL Z2, and Z3 but did not react with Z1 |
| Proposed Epitope | This Mab binds to phosphorylated sugar side chains, which comprise 85% of GP72 carbohydrate and contain ribose, xylose, and fucose |
| IEDB Epitope | N/A |
| Proposed Utility | Anti-T. cruzi monoclonal antibodies are considered to have important applications to epidemiological studies and the improved diagnosis and prognosis of Chagas' disease |
| Curator ID | AA + AS |
| Date of Curation | 01-06-2011 |
| References | 6380014 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |