|
|
|
|
Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us |
|
| PolysacDB ID | 1025 |
| Carbohydrate Name | Capsular polysaccharide A (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Cryptococcus neoformans (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated |
| BCSDB Structure | N/A |
| Proposed Function | The capsular polysaccharide is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Sheep erythrocytes |
| Conjugate Method | The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature |
| Antibodies | Mab 439 |
| Antibody Type Class | IgG1 |
| Assay System | Ouchterlony double immunodiffusion, Phagocytosis assays |
| Cross Reactivity | This antibody cross-reacted with all the 4 serotypes- A, B, C and D |
| Proposed Epitope | The reactivity of this antibody required an intact carboxyl group and also required deacetylation of the parent polysaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | MAb against an epitope shared by all four serotypes may have value for the detection of cryptococcal antigens in body fluids. This antibody also has potent opsonic activity |
| Curator ID | AA + AS |
| Date of Curation | 07-01-2010 |
| References | PMC260621 |
| PolysacDB ID | 1026 |
| Carbohydrate Name | Capsular polysaccharide A (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Cryptococcus neoformans (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated |
| BCSDB Structure | N/A |
| Proposed Function | The capsular polysaccharide is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Sheep erythrocytes |
| Conjugate Method | The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature |
| Antibodies | Mab 1255 |
| Antibody Type Class | IgG1 |
| Assay System | Ouchterlony double immunodiffusion, Phagocytosis assays |
| Cross Reactivity | This antibody cross-reacted with 3 serotypes- A, B and D |
| Proposed Epitope | The reactivity of this antibody required an intact carboxyl group and also required deacetylation of the parent polysaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | MAb against an epitope shared by all four serotypes may have value for the detection of cryptococcal antigens in body fluids. This antibody also has potent opsonic activity |
| Curator ID | AA + AS |
| Date of Curation | 08-01-2010 |
| References | PMC260621 |
|
Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |