PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID1376
Carbohydrate NameCapsular polysaccharide 500 antigen   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NameCryptosporidium parvum   (NCBI Taxonomy)   (Drugpedia)
Basic StructureCPS-500 is a chloroform-extractable glycolipid
BCSDB StructureN/A
Proposed FunctionCPS-500 is a candidate target antigen for active or passive immunization against cryptosporidiosis
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 18.44
Antibody Type ClassIgG3
Assay SystemELISA, immunoblotting
Cross ReactivityN/A
Proposed EpitopeThe neutralization-sensitive epitope recognized by MAb 18.44 is dependent on terminal β-D-mannopyranosyl residues
IEDB EpitopeN/A
Proposed UtilityMAb 18.44 neutralizes the infectivity of both sporozoites and merozoites and to significantly reduce C. parvum infection in oocyst-challenged mice when coadministered with other neutralizing Mab
Curator IDAA + AS
Date of Curation02-07-2010
References2193057

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