PolysacDB ID | 2487 |
Carbohydrate Name | Glycoprotein GP72 (Drugpedia) |
Carbohydrate Class | Glycoprotein |
Microbe | Trypanosoma cruzi Z2 Esmeraldo/3 (NCBI Taxonomy) (Drugpedia) |
Basic Structure | GP72 is a 72-kilodalton cell surface glycoprotein found on epimastigotes and metacyclic trypomastigotes
|
BCSDB Structure | N/A |
Proposed functions | GP72 may regulate T. cruzi morphogenesis in the insect vector |
Antigenic Nature used to produce antibodies | Whole cells |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab WIC 29.26 |
Antibody type and class | IgG2a |
Assay System | ELISA, immunoblotiing, indirect immunofluorescence |
Cross-reactivity | This Mab cross-reacted with T. cruzi BOL Z2, and Z3 but did not react with Z1. WIC 29.26 bound to only 2 of the 4 Trypanozome cruzi strains and 23 of the 50 clones tested |
Proposed epitopes | WIC 29.26 binds to phosphorylated sugar side chains, which comprise 85% of GP72 carbohydrate and contain ribose, xylose, and fucose |
IEDB Epitope | N/A |
Proposed Utility | Anti-T. cruzi monoclonal antibodies are considered to have important applications to epidemiological studies and the improved diagnosis and prognosis of Chagas' disease |
Curator ID | AA + AS |
Date of Curation | 01-06-2011
|
References | 6380014 |