| PolysacDB ID | 1729 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose
|
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Phenolic glycolipid-1 and heat-killed M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab VI703 |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab reacted with deacylated Phenolic glycolipid-1[ PGL-I (PGL-I OH )], but did not bind to PGL antigens from M. kansasii (mycoside A), M. bovis (deacylated mycosideB), and M. tuberculosis (PGL-Tb OH ) |
| Proposed epitopes | The outer monosaccharide, disaccharide and the trisaccharide all contributed to the epitope recognized by this Mab |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab was used for the development of peptide mimotopes resembling the carbohydrate structures recognized by this Mab |
| Curator ID | AA + AS |
| Date of Curation | 17-10-2010
|
| References | 15094167 |