| PolysacDB ID | 2292 |
| Carbohydrate Name | Core oligosaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Shigeila sonnei serotype D (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipopolysaccharide (LPS) molecules consist of three structural regions: a lipid A region, which anchors the molecule in the bacterial outer membrane; an intermediate core region; and a distal, serotype-specific O-polysaccharide chain (O chain or O-antigen). Whereas the chemical composition and structure of 0 chains are highly variable, the core moiety is more conserved. Seven types of LPS core structures, namely, Ra, Ri to R4, K-12, and B, have been found in members of the family Enterobacteriaceae
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| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Heat killed cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab Sh9R |
| Antibody type and class | IgM |
| Assay System | ELISA and immunoblotting |
| Cross-reactivity | Only strains reported to have LPS molecules with an R1-type core structure were recognized, namely, S. sonnei, S. boydii type 3, S. flexneri type 6, a control E. coli R1 strain (HF4704), and an E. coli 09 isolate |
| Proposed epitopes | Terminal hexose residues may form an important part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab has been used to analyze clinical isolates and a hybrid Salmonella typhi strain for their expression of the corresponding LPS moieties. In addition to their use in the screening of candidate vaccine strains, the new MAb provide a powerful tool for epidemiological and phylogenetic studies of natural enterobacterial populations |
| Curator ID | AA + AS |
| Date of Curation | 21-03-2011
|
| References | PMC257229 |