PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2410
Carbohydrate NameType 1b polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeStreptococcus Group B   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesA mixture composed of equal parts of the vaccine suspensions of strains H36B (type Tb), 18RS21 (type II), and 1073 (nontypeable)
Carrier NameNil
Conjugation MethodNil
AntibodiesMab SMB19
Antibody type and classIgM
Assay SystemELISA, indirect immunofluorescence
Cross-reactivityThis Mab reacted specifically with the sialylated form of the type 1b polysaccharide. This Mab cross-reacts with some oligosaccharides in human milk and certain fetal antigens
Proposed epitopesSialyllacto-N-tetraose residues seemed to be the immunodominant epitope
IEDB EpitopeN/A
Proposed UtilityThis Mab will help in the development of appropriate vaccines against GBS that would include the possibility of inducing major cross-reactions with human glycoconjugates
Curator IDAA + AS
Date of Curation02-05-2011
References1548081


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