PolysacDB ID | 1610 |
Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
Carbohydrate Class | Capsular polysaccharide |
Microbe | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
Basic Structure | It is a homopolymer of α(2-->8) sialic acid
|
BCSDB Structure | N/A |
Proposed functions | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
Antigenic Nature used to produce antibodies | A patient suffering from IgM lambda monoclonal gammopathy |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab NOV |
Antibody type and class | IgM |
Assay System | Ouchterlony Gel Diffusion, ELISA, invivo protection assays |
Cross-reactivity | This Mab reacted with group B meningococcal and E. coli K1 capsular polysaccharides and did not react with a(2 --> 9)-linked poly-N-acetylneuraminic acid, the capsular polysaccharide of the group C meningococcus, nor with the capsular polysaccharide of E. coli K92 or K100. It also crossreacts with polynucleotides and denatured DNA |
Proposed epitopes | The epitope was proposed to consist of α(2-->8)-linked poly-N-acetylneuraminic acid |
IEDB Epitope | N/A |
Proposed Utility | This Mab is protective against E. coli in newborn rats |
Curator ID | AA + AS |
Date of Curation | 22-09-2010
|
References | PMC2188242 |