PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2203
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeSerogroup B Salmonella   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Abep2Ac-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp [branched to α-D-Glcp-(1-->6)]-(1-
BCSDB StructureN/A
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MAST 108
Antibody type and classN/A
Assay SystemELISA, enzyme immuno assay
Cross-reactivityN/A
Proposed epitopesThis Mab bound to the O:4 epitope when present in the terminal non-reducing end as well as an intrachain determinant of the O-polysaccharide
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation02-03-2011
References1378926


Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020