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| PolysacDB ID | 2268 |
| Carbohydrate Name | Y O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Shigella flexneri (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Heat-killed S. flexnerf bacteria serotype Y |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab MASF Y-4 |
| Antibody type and class | N/A |
| Assay System | ELISA, FARR assay |
| Cross-reactivity | MASF Y-4 bound to LPS of serotypes 2a. 3b, 4a, 4b, 5a, and Y |
| Proposed epitopes | The terminal nonreducing end of the O-polysaccharide complementary to the tetrasaccharide repeating unit |
| IEDB Epitope | 76696 |
| Proposed Utility | This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide |
| Curator ID | AA + AS |
| Date of Curation | 15-03-2011 |
| References | 2438343 |
| PolysacDB ID | 2284 |
| Carbohydrate Name | O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Shigella flexneri serotype Y (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1--> |
| BCSDB Structure | 3226 |
| Proposed functions | LPS plays an important virulence role based on its antiphagocytic and endotoxic properties |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab MASF Y-4 |
| Antibody type and class | IgM |
| Assay System | ELISA |
| Cross-reactivity | MASF Y-4 antibodies bound to 2a, 3b, 4a, 4b, 5a, and Y LPSs |
| Proposed epitopes | N/A |
| IEDB Epitope | 76891 |
| Proposed Utility | This Mab may prove to be valuable reagents in the studies of protective immunity against Shigella bacteria |
| Curator ID | AA + AS |
| Date of Curation | 18-03-2011 |
| References | 2437036 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |